WEKO3
アイテム
Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein
http://hdl.handle.net/2298/20019
http://hdl.handle.net/2298/20019ff5e3197-1f29-4590-b85e-d78f0e6e8914
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JBMT_24_4_Figures.pdf (164.3 kB)
|
|
|
|
JBMT_24_4_230-234.pdf (131.0 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-07-05 | |||||
| タイトル | ||||||
| タイトル | Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Apigenin, CYP1A2, Docking simulation, Genistein, Inhibitory potency | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
島田, 秀昭
× 島田, 秀昭× Eto, Masashi× Ohtaguro, Misa× Ohtsubo, Michihiro× Mizukami, Yosuke× Ide, Tsuyoshi× 今村, 順茂 |
|||||
| 別言語の著者 |
島田, 秀昭
× 島田, 秀昭× 衞藤, 仁× 大田黒, 弥紗× 大坪, 路弘× 水上, 洋介× 井出, 剛× 今村, 順茂 |
|||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined. Among flavonoids tested, galangin, kaempferol, chrysin, and apigenin were potent inhibitors. Although apigenin belonging to flavones and genistein belonging to isoflavones are similar in the chemical structures, the inhibitory potencies for CYP1A2 were distinguished markedly between these two flavonoids. In computer-docking simulation, apigenin interacted with the same mode of cocrystallized α-naphthoflavone in the active site of CYP1A2, and then the B ring of apigenin was placed close to the heme iron of the enzyme with a single orientation. In contrast, the docked genistein conformation showed two different binding modes, and the A ring of genistein was oriented to the heme iron of CYP1A2. Furthermore, the binding free energy of apigenin was lower than that of genistein. These results demonstrate a possible mechanism that causes the differential inhibitory potencies of apigenin and genistein for CYP1A2. | |||||
| 書誌情報 |
Journal of Biochemical and Molecular Toxicology 巻 24, 号 4, p. 230-234, 発行年 2010-07 |
|||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20806393 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1002/jbt.20328 | |||||
| 権利 | ||||||
| 権利情報 | © 2010 Wiley | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 10956670 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 131021 bytes | |||||
| 形態 | ||||||
| 値 | 164307 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 375.42 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.3 | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://onlinelibrary.wiley.com/doi/10.1002/jbt.20328/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+9+July+from+10-12+BST+for+monthly+maintenance | |||||
