| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2011-07-11 |
| タイトル |
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タイトル |
Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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主題 |
Obesity, Heat shock protein, Inflammation, Mild electrical stimulation, Diabetes |
| 資源タイプ |
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資源タイプ |
journal article |
| 別言語の著者 |
近藤, 龍也
佐々木, 一成
足立, 博紀
中山, 善晴
羽手村, 昌宏
松山, 利奈
水流添, 覚
古川, 昇
本島, 寛之
古賀, 沙緒里
山下, 康行
宮村, 信博
甲斐, 広文
荒木, 栄一
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| 内容記述 |
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内容記述 |
Objective: Obesity induces chronic inflammation, which contributes to the development and progression of insulin resistance, diabetes and atherosclerosis.
We have recently shown that induction of heat shock protein 72 by mild electric current and thermo (MET) treatment in mouse model of type 2 diabetes ameliorated glucose homeostasis and insulin resistance accompanied by reduced adiposity. For clinical application of MET, we confirmed its safety in healthy subjects.
Methods: MET was applied for 10 healthy Japanese male (12V, 55 pulses per second, 30 min at 42oC) twice a week for 8 weeks. Fat volume was measured by CT scan and several parameters were investigated.
Results: MET did not induce any adverse effects nor muscle contraction/pain. There were no significant alterations in glucose homeostasis or insulin resistance. Visceral and subcutaneous fat volume showed a trend of decrease without significant difference (- 3.9% and - 4.3%, respectively), which were restored 8 weeks after withdrawal of MET. Interestingly, serum tumor necrosis factor- (TNF-:0.91 ± 0.05 v.s. 0.67 ± 0.06 pg/mL; p =0.006) and high sensitivity-C reactive protein (hs-CRP: 521.9 ± 73.9 v.s. 270.8 ± 43.7 ng/mL; p=0.023) levels , both of which are associated with chronic inflammation, were significantly decreased.
Conclusion: MET may be beneficial for the reduction of an inflammatory response observed in diabetes and metabolic syndrome. |
| bibliographic_information |
Obesity Research &Clinical Practice
巻 4,
号 2,
p. e101-e109,
発行年 2010-04
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| item_16_source_id_7 |
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収録物識別子 |
1871-403X |
| item_16_relation_11 |
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関連タイプ |
isVersionOf |
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関連識別子 |
10.1016/j.orcp.2009.09.007 |
| 権利 |
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権利情報 |
© 2009 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved |
| 出版タイプ |
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出版タイプ |
AM |
| 日本十進分類法 |
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主題Scheme |
NDC |
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主題 |
493.12 |
| 出版者 |
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出版者 |
Elsevier |
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言語 |
en |
| item_16_description_46 |
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内容記述タイプ |
Other |
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内容記述 |
論文(Article) |
| item_16_text_47 |
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雑誌掲載論文 |
| item_16_text_48 |
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Journal Article |
| item_16_text_49 |
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text |
| item_16_text_50 |
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01 |
| item_16_description_77 |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/article/pii/S1871403X09000817 |
ORCP_4_2_e101-109.pdf (246.5 kB)
