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Chronic Pancreatitis in Mice by Treatment with Choline-Deficient Ethionine-Supplemented Diet
http://hdl.handle.net/2298/20259
http://hdl.handle.net/2298/2025913bd4569-ffe0-4184-9e56-a55a15c2772c
| 名前 / ファイル | ライセンス | アクション |
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59_421.pdf (899.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-07-13 | |||||
| タイトル | ||||||
| タイトル | Chronic Pancreatitis in Mice by Treatment with Choline-Deficient Ethionine-Supplemented Diet | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | CDE diet, chronic pancreatitis, EGFR, Spink3, tubular complex | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
井田, 智
× 井田, 智× Ohmuraya, Masaki× Hirota, Masahiko× Ozaki, Nobuyuki× Hiramatsu, Sayaka× Uehara, Hitoshi× Takamori, Hiroshi× 荒木, 喜美× Baba, Hideo× Yamamura, Ken-ichi |
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| 別言語の著者 |
井田, 智
× 井田, 智× 大村谷, 昌樹× 廣田, 昌彦× 尾崎, 宣之× 平松, さやか× 上原, 仁× 高森, 啓史× 荒木, 喜美× 馬場, 秀夫× 山村, 研一 |
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| 内容記述 | ||||||
| 内容記述 | Although chronic pancreatitis is a risk factor for pancreatic ductal adenocarcinoma (PDA), the relationship between chronic pancreatitis and PDA remains obscure. A critical obstacle to understanding the role of chronic pancreatitis is the lack of animal models. To develop one such model, mice were fed long-term with a choline deficient ethionine-supplemented (CDE) diet. Histological evaluation revealed that chronic pancreatitis, characterized by acinar atrophy, fibrosis and well-developed tubular complexes (TCs), was observed after 24 weeks of CDE diet treatment. Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor α (TGF α) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation. Neoplastic lesions were not found after 54 weeks of treatment, suggesting that a continuation of CDE diet or another insult is required for the development of PDA. | |||||
| 書誌情報 |
Experimental Animals 巻 59, 号 4, p. 421-429, 発行年 2010-07-22 |
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| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20660988 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1538/expanim.59.421 | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 13411357 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 899653 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 480.75 | |||||
| 出版者 | ||||||
| 出版者 | Japanese Association for Laboratory Animal Science | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
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| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.jstage.jst.go.jp/article/expanim/59/4/59_421/_article/-char/ja/ | |||||
