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Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats
http://hdl.handle.net/2298/25981
http://hdl.handle.net/2298/2598121433187-d6b7-4c97-8bdb-5dc68c20f264
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Kusumoto CEN FINAL REPOS.pdf (657.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-12-03 | |||||
| タイトル | ||||||
| タイトル | Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Acute kidney injury, Cisplatin, Indoxyl sulfate, Uremic toxins, Phytochemical polyphenols | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kusumoto, Masahiro
× Kusumoto, Masahiro× 鴨林, 宏樹× Sato, Daisuke× Komori, Megumi× Wakida, Ayaka× Yoshimura, Misato× 濱田, 哲暢× Kohda, Yukimasa× Tomita, Kimio× Saito, Hideyuki |
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| 別言語の著者 |
楠本, 将裕
× 楠本, 将裕× 鴨林, 宏樹× 佐藤, 大介× 小森, めぐみ× 脇田, 紋佳× 吉村, 美里× 濱田, 哲暢× 江田, 幸政× 冨田, 公夫× 齋藤, 秀之 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background:Polyphenols such as quercetin have been reported to prevent cisplatin-induced acute kidney injury (AKI). Indoxyl sulfate (IS), a uremic toxin generated in the liver, is increased in cisplatin AKI. The present study examined the effect of phytochemical polyphenols on serum and renal accumulations of IS in association with cisplatin AKI. Methods:Sprague-Dawley rats were treated with cisplatin (10 mg/kg body weight) by intraperitoneal injection. Polyphenols were orally administered at -24, -1, 24 and 48 hr before or after cisplatin injection. Serum levels of IS, cisplatin, serum creatinine (SCr), blood urea nitrogen (BUN) and electrolytes were measured. By using in vitro assay system with rat liver S9 fraction, the inhibitory potencies of several compounds on IS production were determined. Results:Injection of cisplatin in rats markedly elevated the SCr and BUN levles, which were accompanied by tubular injuries and the expression of kidney injury molecule-1 (Kim-1). By contrast, quercetin significantly suppressed the SCr and BUN levels in the cisplatin-treated rats and protected them against renal injury with the decreased expression of Kim-1. Quercetin had no effect on serum and renal levels of cisplatin. In addition, quercetin had no effect on cisplatin-induced renal accumulation of malondialdehyde. IS concentrations in serum, kidney, liver, intestine and lung were markedly elevated by cisplatin treatment, whereas quercetin suppressed the serum and tissue IS levels. An in vitro kinetic assay revealed that quercetin displayed a potent inhibitory effect on hepatic production of IS. Conclusion:Inhibition of IS accumulation by oral administration of quercetin alleviates cisplatin-induced AKI. |
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| 書誌情報 |
Clinical and Experimental Nephrology 巻 15, 号 6, p. 820-830, 発行年 2011-12 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21858734 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s10157-011-0524-z | |||||
| 権利URI | ||||||
| 値 | © 2011 Springer Japan | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 656983 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499 | |||||
| 出版者 | ||||||
| 出版者 | Springer Japan | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.springerlink.com/content/051w24k21l103266/ | |||||
