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Nerve Growth Factor and the Physiology of Pain: Lessons from Congenital Insensitivity to Pain with Anhidrosis
http://hdl.handle.net/2298/25662
http://hdl.handle.net/2298/2566297bfdb97-50ce-43c4-9e39-3f8ba7eaae50
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-09-27 | |||||
| タイトル | ||||||
| タイトル | Nerve Growth Factor and the Physiology of Pain: Lessons from Congenital Insensitivity to Pain with Anhidrosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | congenital insensitivity to pain (CIP), congenital insensitivity to pain with anhidrosis (CIPA), hereditary sensory and autonomic neuropathy type IV, interoception, NGF-dependent primary afferent neurons, NTRK1 gene, polymodal receptors, receptor tyrosine kinase for NGF, sympathetic neurons, TrkA receptor | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Indo, Yasuhiro
× Indo, Yasuhiro |
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| 別言語の著者 |
犬童, 康弘
× 犬童, 康弘 |
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| 内容記述 | ||||||
| 内容記述 | Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder characterized by insensitivity to pain, anhidrosis (the inability to sweat) and mental retardation. Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and maintenance of NGF-dependent neurons, including primary afferent neurons with thin fibers and sympathetic postganglionic neurons, during development. NGF is also considered to be an inflammatory mediator associated with pain, itch and inflammation in adults. CIPA results from loss-of-function mutations in the NTRK1 gene-encoding TrkA (tropomyosin-related kinase A), a receptor tyrosine kinase for NGF. Defects in NGF-TrkA signal transduction lead to the failure of survival of various NGF-dependent neurons. As a result, patients with CIPA lack NGF-dependent neurons. Recent studies have revealed that mutations in the NGFB gene-encoding NGF protein also cause congenital insensitivity to pain.Using the pathophysiology of CIPA as a foundation, this review investigates the ways in which NGF-dependent neurons contribute to interoception, homeostasis and emotional responses and, together with the brain, immune and endocrine systems, play crucial roles in pain, itch and inflammation. The NGF-TrkA system is essential for the establishment of neural networks for interoception, homeostasis and emotional responses. These networks mediate reciprocal communication between the brain and the body in humans. |
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| 書誌情報 |
Clinical Genetics 巻 82, 号 4, p. 341-350, 発行年 2012-10 |
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| ISSN | ||||||
| 収録物識別子 | 00099163 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1111/j.1399-0004.2012.01943.x | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Blackwell Publishing | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | AM | |||||
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| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
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| 出版者 | Blackwell Publishing | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0004.2012.01943.x/abstract | |||||
