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  1. 医学
  2. 発表論文(医学系)

Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression

http://hdl.handle.net/2298/26061
http://hdl.handle.net/2298/26061
3d2ca88b-ea07-4b94-90fc-f8c347b29448
名前 / ファイル ライセンス アクション
Breast Breast Cancer Research and Treatmen 2011.VOL130.Figure.pdf (442.1 kB)
Breast Breast Cancer Research and Treatmen 2011.VOL130.pdf (379.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-13
タイトル
タイトル Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression
言語
言語 eng
キーワード
主題 Insulin-like growth factor-1 receptor, Breast cancer, Prognosis
資源タイプ
資源タイプ journal article
著者 Fu, Peifen

× Fu, Peifen

WEKO 120710

Fu, Peifen

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Ibusuki, Mutsuko

× Ibusuki, Mutsuko

WEKO 120711

Ibusuki, Mutsuko

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山本, 豊

× 山本, 豊

WEKO 105822

ja 山本, 豊
ISNI

ja-Kana ヤマモト, ユタカ

en Yamamoto, Yutaka

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Hayashi, Mitsuhiro

× Hayashi, Mitsuhiro

WEKO 120713

Hayashi, Mitsuhiro

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村上, 敬一

× 村上, 敬一

WEKO 120798

ja 村上, 敬一
ISNI

ja-Kana ムラカミ, ケイイチ

en Murakami, Keiichi

Search repository
Zheng, Shusen

× Zheng, Shusen

WEKO 120715

Zheng, Shusen

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Iwase, Hirotaka

× Iwase, Hirotaka

WEKO 120716

Iwase, Hirotaka

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別言語の著者 指宿, 睦子

× 指宿, 睦子

WEKO 120722

指宿, 睦子

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山本, 豊

× 山本, 豊

WEKO 120723

山本, 豊

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林, 光博

× 林, 光博

WEKO 120724

林, 光博

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村上, 敬一

× 村上, 敬一

WEKO 120725

村上, 敬一

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岩瀬, 弘敬

× 岩瀬, 弘敬

WEKO 120726

岩瀬, 弘敬

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内容記述
内容記述 Insulin-like growth factor-1 receptor (IGF1R) plays a key role in the initiation and progression of breast cancer. However, its prognostic relevance to breast cancer patients has long been a matter of debate. In a series of 325 primary invasive breast cancer patients, we performed a comprehensive analysis of IGF1R at the levels of gene copy number, mRNA expression and protein expression. The relationship between the IGF1R status and the clinicopathological characteristics and prognosis was evaluated. IGF1R mRNA levels not only correlated with protein expression, but also significantly associated with several clinicopathological parameters and prognosis of the patients. Patients with low nuclear grade, negative axillary lymph node, positive hormone receptor, negative HER2, negative Ki67 and luminal subtype tumors showed higher level expression of IGF1R mRNA, which was shown to be a significant univariate parameter for both relapse free survival (RFS) and breast cancer specific survival (BCSS) as well as significant multivariate parameter for BCSS. IGF1R protein expression showed an association with a prolonged BCSS in univariate analysis. By contrast, IGF1R gene copy number did not correlated with mRNA and protein expression, and harbored no prognostic value. When studied in breast tumor subtype groups relatively, IGF1R mRNA level was still significantly associated with a better BCSS. Overall, our data indicated a correlation among IGF1R mRNA expression and protein expression in primary breast cancer. In particular, the IGF1R mRNA expression appeared to be a good prognostic marker either in the entire cohort or in the luminal subtype group. These data may serve as background information for IGF1R-targeted therapy.
書誌情報 Breast Cancer Research and Treatment

巻 130, 号 1, p. 307-317, 発行年 2011-11
ISSN
収録物識別子 01676806
DOI
関連識別子 10.1007/s10549-011-1605-0
権利
権利情報 © 2012 Springer New York
フォーマット
内容記述 application/pdf
フォーマット
内容記述 application/pdf
フォーマット
内容記述 application/pdf
フォーマット
内容記述 application/pdf
形態
379671 bytes
形態
442140 bytes
形態
58418 bytes
形態
58418 bytes
著者版フラグ
出版タイプ AM
日本十進分類法
主題 495.46
出版者
出版者 Springer New York
資源タイプ
内容記述 論文(Article)
資源タイプ・ローカル
雑誌掲載論文
資源タイプ・NII
Journal Article
資源タイプ・DCMI
text
資源タイプ・ローカル表示コード
01
URL
内容記述 http://link.springer.com/article/10.1007%2Fs10549-011-1605-0
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