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  1. 医学
  2. 発表論文(医学系)

Evaluation of tumor stiffness by elastography is predictive for pathologic complete response to neoadjuvant chemotherapy in patients with breast cancer

http://hdl.handle.net/2298/29403
http://hdl.handle.net/2298/29403
0fca46a9-77c5-41d0-8b9a-a8bddd3039d2
名前 / ファイル ライセンス アクション
Annals Annals of Surgical Oncology 2012 VOL19-9.pdf (355.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-02-24
タイトル
タイトル Evaluation of tumor stiffness by elastography is predictive for pathologic complete response to neoadjuvant chemotherapy in patients with breast cancer
言語
言語 eng
キーワード
主題 Breast elastography, tumor stiffness, neoadjuvant chemotherapy
資源タイプ
資源タイプ journal article
著者 Hayashi, Mitsuhiro

× Hayashi, Mitsuhiro

WEKO 120771

Hayashi, Mitsuhiro

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山本, 豊

× 山本, 豊

WEKO 105822

ja 山本, 豊
ISNI

ja-Kana ヤマモト, ユタカ

en Yamamoto, Yutaka

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Ibusuki, Mutsuko

× Ibusuki, Mutsuko

WEKO 120773

Ibusuki, Mutsuko

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Fujiwara, Saori

× Fujiwara, Saori

WEKO 120774

Fujiwara, Saori

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山本, 聡子

× 山本, 聡子

WEKO 120795

ja 山本, 聡子
ISNI

ja-Kana ヤマモト, サトコ

en Yamamoto, Satoko

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Tomita, Saori

× Tomita, Saori

WEKO 120776

Tomita, Saori

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Nakano, Masahiro

× Nakano, Masahiro

WEKO 120777

Nakano, Masahiro

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村上, 敬一

× 村上, 敬一

WEKO 120798

ja 村上, 敬一
ISNI

ja-Kana ムラカミ, ケイイチ

en Murakami, Keiichi

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Iyama, Kenichi

× Iyama, Kenichi

WEKO 120779

Iyama, Kenichi

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Iwase, Hirotaka

× Iwase, Hirotaka

WEKO 120780

Iwase, Hirotaka

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別言語の著者 林, 光博

× 林, 光博

WEKO 120791

林, 光博

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山本, 豊

× 山本, 豊

WEKO 120792

山本, 豊

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指宿, 睦子

× 指宿, 睦子

WEKO 120793

指宿, 睦子

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藤原, 沙織

× 藤原, 沙織

WEKO 120794

藤原, 沙織

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山本, 聡子

× 山本, 聡子

WEKO 120795

ja 山本, 聡子
ISNI

ja-Kana ヤマモト, サトコ

en Yamamoto, Satoko

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冨田, さおり

× 冨田, さおり

WEKO 120796

冨田, さおり

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中野, 正啓

× 中野, 正啓

WEKO 120797

中野, 正啓

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村上, 敬一

× 村上, 敬一

WEKO 120798

ja 村上, 敬一
ISNI

ja-Kana ムラカミ, ケイイチ

en Murakami, Keiichi

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猪山, 賢一

× 猪山, 賢一

WEKO 120799

猪山, 賢一

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岩瀬, 弘敬

× 岩瀬, 弘敬

WEKO 120800

岩瀬, 弘敬

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内容記述
内容記述 Background: Breast elastography (EG), which can objectively evaluate tumor stiffness, has been useful for differentiation of benign and malignant breast lesions. However, the value of EG for prediction of response to systemic therapy is poorly understood.
Methods: The baseline evaluations of EG in 55 patients who received neoadjuvant chemotherapy were reviewed. We investigated the correlation between tumor stiffness and response to neoadjuvant chemotherapy. Tumor stiffness was evaluated using the Tsukuba elasticity scoring system.
Results: The mean EG scores were significant lower for the clinical and pathological complete response (pCR) groups than for the others. When we categorized patients into two groups according to tumor stiffness, 26 patients were assigned to the low EG group (soft, scores from I to III) and 29 patients were assigned to the high EG group (hard, score IV and V). The low EG group had significantly higher clinical CR and pCR rates than the high EG group (clinical CR, low EG group 38% vs. high EG group 10%, P = 0.024; pCR, low EG group 50% vs. high EG group 14%, P = 0.003, respectively). Furthermore, multivariate analysis indicated that ER, HER2, and low EG (odds ratio 13.04, 95% CI 1.19 to 458.28, P = 0.035) were independent predictive factors of pCR.
Conclusion: Our data demonstrate that tumor stiffness evaluated by EG bears predictive potential for response to neoadjuvant chemotherapy. Stiffness evaluated by EG may be recognized as a clinically significant tumor characteristic, comparable to other data obtained by functional imaging techniques.
書誌情報 Annals of Surgical Oncology

巻 19, 号 9, p. 3042-3049, 発行年 2012-09
ISSN
収録物識別子 10689265
DOI
関連識別子 10.1245/s10434-012-2343-1
権利
権利情報 © 2012 Springer New York
フォーマット
内容記述 application/pdf
形態
355323 bytes
著者版フラグ
出版タイプ AM
日本十進分類法
主題 495
出版者
出版者 Springer New York
資源タイプ
内容記述 論文(Article)
資源タイプ・ローカル
雑誌掲載論文
資源タイプ・NII
Journal Article
資源タイプ・DCMI
text
資源タイプ・ローカル表示コード
01
URL
内容記述 http://link.springer.com/article/10.1245%2Fs10434-012-2343-1
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