WEKO3
アイテム
Hearing impairment in SMS1 deficient mice
http://hdl.handle.net/2298/26710
http://hdl.handle.net/2298/26710a777bfa3-8e6a-4cab-8a90-6259c87742cd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
51-0014.pdf (10.2 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2013-02-01 | |||||
| タイトル | ||||||
| タイトル | Hearing impairment in SMS1 deficient mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | thesis | |||||
| 著者 |
呂, 美紅
× 呂, 美紅 |
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| 別言語の著者 |
Lu, Mei-Hong
× Lu, Mei-Hong |
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| 内容記述 | ||||||
| 内容記述 | Sphingomyelin (SM), a major species of sphingolipids, is a ubiquitous component of cell membranes and plays vital roles in signal transduction and cell growth and survival. However, its physiological functions have not been fully elucidated. Here we have examined the role of SM synthesis mediated by SM synthase (SMS) family members, SMS1 and SMS2, in auditory function. Hearing ability of SMS1 null mice, assessed with an association learning experiment and with auditory brainstem response, was impaired, especially at low frequency range; the impairment was accompanied by abnormalities of stria vascularis (SV), i.e., a decrease in the width of SV and a disorganization of marginal cells. Further, fluorescent immunostaining and western blotting revealed an altered expression pattern and reduced level of KCNQ1 channels in marginal cells. In addition, SMS1 knockout (KO) mice exhibited a significant decrease of endocochlear potential and distortion product otoacoustic emissions, suggesting the defects of cochlear functions. And observation of more macrophage invasion into SV at apical region than other regions may explain the low frequency hearing loss in these SMS1 KO mice. Mice lacking SMS2, however, showed no detectable hearing loss. Taken together, our results suggest hearing impairment in SMS1 deficient mice but not in SMS2 deficient mice. Defects in SV may at least in part account for the hearing impairment in SMS1 deficient mice. |
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| 書誌情報 | 発行年 2012-09-25 | |||||
| フォーマット | ||||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 10236877 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題 | 377.5 | |||||
| その他の言語のタイトル | ||||||
| その他のタイトル | SMS1欠損マウスにおける難聴 | |||||
| タイトル（ヨミ） | ||||||
| その他のタイトル | SMS1 ケッソン マウス ニオケル ナンチョウ | |||||
| 出版者 | ||||||
| 出版者 | 熊本大学 | |||||
| 資源タイプ | ||||||
| 内容記述 | 学位論文(Thesis) | |||||
| 資源タイプ・ローカル | ||||||
| 博士論文 | ||||||
| 資源タイプ・NII | ||||||
| Thesis or Dissertation | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 03 | ||||||
| コメント | ||||||
| 熊本大学大学院医学教育部 医学専攻 | ||||||
| 学位番号 | ||||||
| 甲博生命第14号 | ||||||
