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Strain difference of cadmium accumulation by liver slices of inbred Wistar-Imamichi and Fischer 344 rats
http://hdl.handle.net/2298/27241
http://hdl.handle.net/2298/27241543f7213-f82d-4b0f-a192-20a12c5cd4a6
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Table 1.pdf (30.0 kB)
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Fig. 3.pdf (48.2 kB)
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Fig. 2.pdf (12.9 kB)
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Fig. 1.pdf (12.2 kB)
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Toxicology in Vitro 2008VOL22-2 .pdf (111.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-03-11 | |||||
| タイトル | ||||||
| タイトル | Strain difference of cadmium accumulation by liver slices of inbred Wistar-Imamichi and Fischer 344 rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Cadmium accumulation, Rat liver slice, Strain difference, Zinc transport system | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
島田, 秀昭
× 島田, 秀昭× Yasutake, Akira× Hirashima, Takaomi× Takamure, Yasutaka× 北野, 健× Waalkes, Michael P.× 今村, 順茂 |
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| 別言語の著者 |
島田, 秀昭
× 島田, 秀昭× 安武, 章× 平島, 隆臣× 高群, 泰隆× 北野, 健× Waalkes, Michael P. |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Strain difference in the accumulation of cadmium (Cd) by liver slices was examined in inbred Cd-resistant Wistar-Imamichi (WI) and Cd-sensitive Fischer 344 (F344) rats. The accumulation of Cd by liver slices of WI rats was significantly lower than that of F344 rats, suggesting strain-related differences in the transport of Cd into the liver cells of these two rat strains. In addition, a similar strain difference was observed in the accumulation of zinc (Zn) by liver slices from WI and F344 rats. Cd accumulation by F344 liver slices decreased when Zn was added to the medium in combination with Cd. Furthermore, in F344 liver slices, Zn accumulation was significantly decreased when Cd was added to the medium. These results suggest that the accumulation of Cd by the liver is probably mediated, at least in part, by Zn transport systems. However, we found no strain difference in hepatic ZnT3 or ZIP3 transcript levels between WI and F344 rats. Further work is in progress to identify the transporter that causes the strain differences in hepatic Cd accumulation seen with WI and F344 rats. | |||||
| 書誌情報 |
Toxicology in Vitro 巻 22, 号 2, p. 338-343, 発行年 2008-03 |
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| ISSN | ||||||
| 収録物識別子 | 08872333 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 17980552 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.tiv.2007.09.013 | |||||
| 権利 | ||||||
| 権利情報 | © 2008 Elsevier Limited | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
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| 出版者 | Elsevier Limited | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 値 | 雑誌掲載論文 | |||||
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| 値 | Journal Article | |||||
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| 値 | text | |||||
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| 値 | 01 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S0887233307002597 | |||||
