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Several distinct enzymes catalyze 20α-hydroxysteroid dehydrogenase activity in mouse liver and kidney
http://hdl.handle.net/2298/27242
http://hdl.handle.net/2298/2724268ca250d-f576-4797-97d4-8d0d62cd218c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-11 | |||||
| タイトル | ||||||
| タイトル | Several distinct enzymes catalyze 20α-hydroxysteroid dehydrogenase activity in mouse liver and kidney | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | 20α-Hydroxysteroid dehydrogenase activity, Mouse liver, Mouse kidney, Cofactor requirement, Inhibitors, Activators | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
今村, 順茂
× 今村, 順茂× Ohtaguro, Misa× 島田, 秀昭 |
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| 別言語の著者 |
今村, 順茂
× 今村, 順茂× 大田黒, 弥紗× 島田, 秀昭 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The effects of flavonoids and quinones on NADPH- and NADH-dependent 20α-hydroxysteroid dehydrogenase (20α-HSD) activities were examined in cytosolic fractions from the liver and kidney of mice. Judging from the data for the inhibition of NADPH- and NADH-dependent 20α-HSD activities by flavonoids and quinones, enzyme catalyzing renal NADPH-dependent 20α-HSD activity was found to be distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20α-HSD activities. Sulfobromophthalein (SBP) had little ability to inhibit hepatic NADPH-dependent 20α-HSD activity and bromophenol blue (BPB) exhibited a weak activation against the enzyme activity, whereas SBP and BPB were potent and moderate inhibitors, respectively, of hepatic NADH-dependent 20α-HSD activity. Thus, enzyme catalyzing hepatic NADPH-dependent 20α-HSD activity appeared to be distinct from enzyme catalyzing hepatic NADH-dependent 20α-HSD activity. The data for the pH profiles of hepatic NADPH- and NADH-dependent 20α-HSD activities also led us to the conclusion. Based on these results, we propose the possibility that several distinct enzymes catalyze NADPH- and NADH-dependent 20α-HSD activities in cytosolic fractions from the liver and kidney of mice. | |||||
| 書誌情報 |
Journal of Steroid Biochemistry & Molecular Biology 巻 107, 号 1-2, p. 120-126, 発行年 2007-10 |
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| ISSN | ||||||
| 収録物識別子 | 09600760 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 17629694 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.jsbmb.2007.02.010 | |||||
| 権利 | ||||||
| 権利情報 | © 2007 Elsevier Limited | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
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| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
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| 出版者 | Elsevier Limited | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 値 | 雑誌掲載論文 | |||||
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| 値 | Journal Article | |||||
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| 値 | text | |||||
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| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S0960076007001549 | |||||
