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Inhibitory effects of diesel exhaust components and flavonoids on 20α-hydroxysteroid dehydrogenase activity in mouse tissues
http://hdl.handle.net/2298/27243
http://hdl.handle.net/2298/272432bc34aab-717a-4446-bf46-f74bddf329fb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-11 | |||||
| タイトル | ||||||
| タイトル | Inhibitory effects of diesel exhaust components and flavonoids on 20α-hydroxysteroid dehydrogenase activity in mouse tissues | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | 20α-Hydroxysteroid dehydrogenase activity, diesel exhaust components, flavonoids, mouse tissues, inhibitory potency | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
島田, 秀昭
× 島田, 秀昭× Ohtaguro, Misa× Miura, Kazumi× 今村, 順茂 |
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| 別言語の著者 |
島田, 秀昭
× 島田, 秀昭× 大田黒, 弥紗× 三浦, かずみ× 今村, 順茂 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The inhibitory effects of diesel exhaust components and flavonoids on 20α-hydroxysteroid dehydrogenase (20α-HSD) activity were examined in cytosolic fractions from the liver, kidney and lung of male mice. 9,10-Phenanthrenequinone (9,10-PQ) and 1,2-naphthoquinone (1,2-NQ), which are contained in diesel exhaust particles (DEPs), potently inhibited 20α-HSD activity in liver cytosol. 9,10-PQ also inhibited the enzyme activity in lung cytosol. However, 20α-HSD activity in kidney cytosol was little inhibited by 9,10-PQ or 1,2-NQ. Flavonoids such as quercetin, fisetin and kaempferol exhibited high inhibitory potencies for 20α-HSD activity in liver cytosol, whereas these flavonoids were poor inhibitors for the enzyme activity in kidney cytosol. It is likely that several diesel exhaust components and flavonoids augment the signaling of progesterone in the liver cells, by inhibiting potently 20α-HSD activity in mouse liver cytosol. The possibility that there are distinct enzymes catalyzing 20α-HSD activity in non-reproductive tissues of male mice is also discussed. | |||||
| 書誌情報 |
Journal of Enzyme Inhibition and Medicinal Chemistry 巻 22, 号 4, p. 445-449, 発行年 2007-08 |
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| ISSN | ||||||
| 収録物識別子 | 14756366 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1080/14756360601162113 | |||||
| 権利 | ||||||
| 権利情報 | © 2007 Informa Healthcare | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
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| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
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| 出版者 | Informa Healthcare | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 値 | 雑誌掲載論文 | |||||
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| 値 | Journal Article | |||||
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| 値 | 01 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://informahealthcare.com/doi/abs/10.1080/14756360601162113 | |||||
