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Involvement of carbonyl reductase in superoxide formation through redox cycling of adrenochrome and 9,10-phenanthrenequinone in pig heart
http://hdl.handle.net/2298/27264
http://hdl.handle.net/2298/27264932c5648-1fbc-4f2b-9ad4-244bef095373
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-13 | |||||
| タイトル | ||||||
| タイトル | Involvement of carbonyl reductase in superoxide formation through redox cycling of adrenochrome and 9,10-phenanthrenequinone in pig heart | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Adrenochrome, 9,10-Phenanthrenequinone, Carbonyl reductase, Superoxide formation, Pig heart | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Oginuma, Michiko
× Oginuma, Michiko× 島田, 秀昭× 今村, 順茂 |
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| 別言語の著者 |
荻沼, 道子
× 荻沼, 道子× 島田, 秀昭× 今村, 順茂 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The effects of adrenochrome, a metabolite of epinephrine (adrenaline), and 9,10-phenanthrenequinone (PQ), a component of diesel exhaust particles, on the stereoselective reduction of 4-benzoylpyridine (4-BP) were examined in pig heart cytosol. PQ was a potent inhibitor for the 4-BP reduction, while adrenochrome was a poor inhibitor. A similar result was observed in the effects of adrenochrome and PQ on the reduction of all-trans retinal. Furthermore, although PQ mediated efficiently the formation of superoxide anion radical through its redox cycling in pig heart cytosol, adrenochrome had no ability to mediate the superoxide formation. These may be because the reactivity for adrenochrome, catalyzed by pig heart carbonyl reductase (PHCR), is much lower than that for PQ. The optimal pH for the reduction of PQ in pig heart cytosol was around 5.5. Dicumarol, a potent inhibitor of DT-diaphorase, had little effect on the time course of NADPH oxidation during the reduction of PQ. Therefore, it is concluded that PHCR plays a critical role in superoxide formation through redox cycling of PQ. | |||||
| 書誌情報 |
Chemico-Biological Interactions 巻 155, 号 3, p. 148-154, 発行年 2005-08-15 |
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| ISSN | ||||||
| 収録物識別子 | 00092797 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 16026774 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.cbi.2005.06.002 | |||||
| 権利 | ||||||
| 権利情報 | © 2005 Elsevier Ireland Ltd | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
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| 主題Scheme | NDC | |||||
| 主題 | 464 | |||||
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| 出版者 | Elsevier Ireland Ltd | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 値 | 雑誌掲載論文 | |||||
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| 値 | Journal Article | |||||
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| 値 | text | |||||
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| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S0009279705001717 | |||||
