WEKO3
アイテム
Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease
http://hdl.handle.net/2298/27266
http://hdl.handle.net/2298/27266180d4372-15a1-451a-999d-82b4d26081f0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-13 | |||||
| タイトル | ||||||
| タイトル | Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Long-Evans Cinnamon rats | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | N-benzyl-D-glucamine dithiocarbamate | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Wilson's disease | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Shimada, Hideaki
× Shimada, Hideaki× Takahashi, Makiko× Shimada, Akinori× Okawara, Tadashi× Yasutake, Akira× Imamura, Yorishige× Kiyozumi, Morio |
|||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Long-Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson’s disease in humans. We compared the effects of three metal chelating agents, N-benzyl-D-glucamine dithiocarbamate (BGD), D-penicillamine (D-PEN), and triethylenetetramine (TETA) on the biliary and urinary excretions of Cu using LEC rats. The animals were treated ip with each chelating agent (1 mmol/kg body weight) and then the bile and urine samples were collected for 3 h. Since the single treatment with BGD markedly stimulated biliary excretion of Cu, the protective effect of repeated BGD injection on spontaneous hepatocellular damage was further examined. Separate groups received two weekly injections of BGD starting at 11 weeks of age and were compared to saline injected controls. Serum alanine aminotransferase (ALT) activity and bilirubin level were significantly increased in control LEC rats by 19 weeks of age and histopathological analysis demonstrated extensive hepatic damage in these rats. However, repeated BGD injections prevented the increases in serum ALT and bilirubin and blocked the histopathological changes in the liver. Furthermore, although Cu rapidly accumulated in the liver, kidney, spleen and serum of control LEC rats during the test period, repeated BGD injection largely prevented these increases. These results indicate that BGD treatment is effective in blocking excessive Cu accumulation in LEC rats which, in turn, provides protection from spontaneous liver damage. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Toxicology and Applied Pharmacology 巻 202, 号 1, p. 59-67, 発行日 2005-01-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0041-008X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.taap.2004.06.005 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2005 Academic Press Inc. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 出版者 | ||||||
| 出版者 | Academic Press Inc. | |||||
| 言語 | en | |||||
