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  1. 教育学
  2. 発表論文(教育)

Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease

http://hdl.handle.net/2298/27266
http://hdl.handle.net/2298/27266
180d4372-15a1-451a-999d-82b4d26081f0
名前 / ファイル ライセンス アクション
Fig8.pdf Fig8.pdf (10.8 kB)
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Fig1.pdf Fig1.pdf (7.6 kB)
TAP.202.59-67.pdf TAP.202.59-67.pdf (85.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-03-13
タイトル
タイトル Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Long-Evans Cinnamon rats
キーワード
言語 en
主題Scheme Other
主題 N-benzyl-D-glucamine dithiocarbamate
キーワード
言語 en
主題Scheme Other
主題 Wilson's disease
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Shimada, Hideaki

× Shimada, Hideaki

WEKO 78310

en Shimada, Hideaki

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Takahashi, Makiko

× Takahashi, Makiko

WEKO 147513

en Takahashi, Makiko

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Shimada, Akinori

× Shimada, Akinori

WEKO 147512

en Shimada, Akinori

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Okawara, Tadashi

× Okawara, Tadashi

WEKO 147514

en Okawara, Tadashi

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Yasutake, Akira

× Yasutake, Akira

WEKO 147507

en Yasutake, Akira

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Imamura, Yorishige

× Imamura, Yorishige

WEKO 147196

en Imamura, Yorishige

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Kiyozumi, Morio

× Kiyozumi, Morio

WEKO 149938

en Kiyozumi, Morio

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内容記述
内容記述タイプ Other
内容記述 The Long-Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson’s disease in humans. We compared the effects of three metal chelating agents, N-benzyl-D-glucamine dithiocarbamate (BGD), D-penicillamine (D-PEN), and triethylenetetramine (TETA) on the biliary and urinary excretions of Cu using LEC rats. The animals were treated ip with each chelating agent (1 mmol/kg body weight) and then the bile and urine samples were collected for 3 h. Since the single treatment with BGD markedly stimulated biliary excretion of Cu, the protective effect of repeated BGD injection on spontaneous hepatocellular damage was further examined. Separate groups received two weekly injections of BGD starting at 11 weeks of age and were compared to saline injected controls. Serum alanine aminotransferase (ALT) activity and bilirubin level were significantly increased in control LEC rats by 19 weeks of age and histopathological analysis demonstrated extensive hepatic damage in these rats. However, repeated BGD injections prevented the increases in serum ALT and bilirubin and blocked the histopathological changes in the liver. Furthermore, although Cu rapidly accumulated in the liver, kidney, spleen and serum of control LEC rats during the test period, repeated BGD injection largely prevented these increases. These results indicate that BGD treatment is effective in blocking excessive Cu accumulation in LEC rats which, in turn, provides protection from spontaneous liver damage.
言語 en
書誌情報 en : Toxicology and Applied Pharmacology

巻 202, 号 1, p. 59-67, 発行日 2005-01-01
ISSN
収録物識別子タイプ PISSN
収録物識別子 0041-008X
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.taap.2004.06.005
権利
権利情報 (C) 2005 Academic Press Inc.
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
日本十進分類法
主題Scheme NDC
主題 491
出版者
出版者 Academic Press Inc.
言語 en
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