WEKO3
アイテム
エイズウイルスタンパク質の分子機能に関する研究
http://hdl.handle.net/2298/31761
http://hdl.handle.net/2298/31761a25e7f33-0342-4f47-93e2-44613a58c7bd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
0031-6903v133_1103-1111.pdf (556.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-01-23 | |||||
| タイトル | ||||||
| タイトル | エイズウイルスタンパク質の分子機能に関する研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題 | human immunodeficiency virus, viral protein X (Vpx), Gag, acquired immunodeficiency syndrome, SAMHD1, PI (4,5) P2 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
藤田, 美歌子
× 藤田, 美歌子 |
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| 別言語の著者 |
Fujita, Mikako
× Fujita, Mikako |
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| 内容記述 | ||||||
| 内容記述 | Human immunodeficiency virus (HIV) has no more than nine genes expressing approximately twenty proteins. When T lymphocytes and macrophages in a body are infected with HIV, these proteins work in turn at specific time and location, causing acquired immunodeficiency syndrome (AIDS), a disease yet to be overcome. Since the elucidation of molecular mechanism of HIV proteins should lead to remedy of AIDS, the author has been engaged in the study of HIV protein in the past decade. Described herein are viral protein X (Vpx), uniquely found in HIV-2,and its homologous protein Vpr found both in HIV-1 and -2. We found that Vpx enhances genome nuclear import in T lymphocytes, and is critical for reverse transcription of viral RNA in macrophages. This finding on the function in macrophages corrected long-term misleading belief. Furthermore, functional region mapping of Vpx was performed. In 2011, the protein SAMHD1 was identified as the host restriction factor counteracted by Vpx, by foreign researchers. After that, our independent study demonstrated the presence of SAMHD1-independent functions of Vpx in T cells, in addition to its SAMHD1-dependent functions in macrophages. Another topic of this review is Gag protein. Recently, it has reported by oversea researchers that PI(4,5)P2(one of phosphoinositide) regulates Pr55^<Gag> localization and assembly. In this study, we determined the binding affinity between N-terminal MA domain of Pr55^<Gag> and various phosphoinositide derivatives using surface plasmon resonance. The results suggested that both negatively charged inositol phosphates and hydrophobic acyl chain are required for the MA binding. | |||||
| 書誌情報 |
藥學雑誌 巻 133, 号 10, p. 1103-1111, 発行年 2013-10 |
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| ISSN | ||||||
| 収録物識別子 | 00316903 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00284903 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1248/yakushi.13-00200 | |||||
| 権利 | ||||||
| 権利情報 | © 2013 The Pharmaceutical Society of Japan | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 556397 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| その他の言語のタイトル | ||||||
| その他のタイトル | Study on Molecular Function of Proteins of Human Immunodeficiency Virus | |||||
| タイトル（ヨミ） | ||||||
| その他のタイトル | エイズ ウイルス タンパクシツ ノ ブンシ キノウ ニ カンスル ケンキュウ | |||||
| 出版者 | ||||||
| 出版者 | 日本薬学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
