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Insulin Resistance and Hepatocarcinogenesis
http://hdl.handle.net/2298/33063
http://hdl.handle.net/2298/330633fe866a7-b37c-4b71-bae4-0ff9676d043e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CJG_3(6)_271-278.pdf (230.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-09-17 | |||||
| タイトル | ||||||
| タイトル | Insulin Resistance and Hepatocarcinogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | insulin resistance, obesity, insulin, IGF-1, oxidative stress, HCC | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sasaki, Yutaka
× Sasaki, Yutaka |
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| 別言語の著者 |
佐々木, 裕
× 佐々木, 裕 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Hepatocellular carcinoma (HCC) accounts for 85–90% of liver cancers and is one of the most frequent carcinomas in the world. HCCs classically develop against the background of chronic liver diseases. Common causes of such liver diseases are viral hepatitis, alcoholic hepatitis, or immune-related diseases. However, 15–50% of patients with HCCs have none of these classic antecedents, especially in developed countries. In this context, obesity and diabetes mellitus have been found to exhibit an increased risk of HCC. Both conditions are associated with insulin resistance. The tumorigenic effects of insulin resistance and complementary hyperinsulinemia could be mediated directly by insulin signaling, or indirectly related to changes in endogeneous hormone metabolism, particularly IGF-1 (insulin-like growth factor I). Conversely, insulin resistance may be a consequence of obesity and hepatic inflammation, both of which can themselves promote tumorigenesis, mainly through cytokine production and/or generation of oxidative stress. Because the prevalence of obesity is now increasing throughout the world, insulin resistance is sure to be put more forth as a central factor for hepatocarcinogenesis in the foreseeable future. | |||||
| 書誌情報 |
Clinical Journal of Gastroenterology 巻 3, 号 6, p. 271-278, 発行年 2010-12 |
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| ISSN | ||||||
| 収録物識別子 | 18657257 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12646624 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s12328-010-0177-6 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 230558 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.47 | |||||
| 出版者 | ||||||
| 出版者 | Springer Japan | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://link.springer.com/article/10.1007%2Fs12328-010-0177-6 | |||||
| コメント | ||||||
| 値 | The final publication is available at Springer via http://dx.doi.org/10.1007/s12328-010-0177-6. | |||||
| コメント | ||||||
| 値 | 【著者所属】大学院生命科学研究部(臨床系) 消化器内科学 | |||||
