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Nuclear Phosphoproteomics Features the Novel Smoking Markers in Mouse Lung Tissue Following Subacute Phase Exposure to Tobacco Smoke
http://hdl.handle.net/2298/36161
http://hdl.handle.net/2298/361615b1957c5-a7e8-4362-8905-a97ba3655fef
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JBAB8(1)_9-16.pdf (659.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-02-20 | |||||
| タイトル | ||||||
| タイトル | Nuclear Phosphoproteomics Features the Novel Smoking Markers in Mouse Lung Tissue Following Subacute Phase Exposure to Tobacco Smoke | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Nuclear phosphoproteomics, Subacute phase, Tobacco smoke, Lung, RAGE, SIK2 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Niimori-Kita, Kanako
× Niimori-Kita, Kanako× 中村, 富美子× Koizumi, Daikai× Niimori, Daisuke |
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| 別言語の著者 |
新森, 加納子
× 新森, 加納子× 中村, 富美子× 小泉, 大海× 新森, 大佑 |
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| 内容記述 | ||||||
| 内容記述 | Smoking is a risk factor of lung diseases including chronic obstructive pulmonary disease (COPD) and lung cancer. However, the molecular mechanisms inducing these diseases remain to be completely uncovered. In order to elucidate them, it is necessary to identify the signaling pathway activated by tobacco smoking exposure. Especially, it is important to identify nuclear phosphoproteins induced by tobacco smoking exposure because the signaling pathways are modified by phosphoproteins. This time, to identify nuclear phosphoproteins as novel smoking markers, nuclear phosphoproteimics of mouse lung tissue following tobacco smoking exposure was examined. Tobacco smoking exposure against mice was examined using the nose-only, flow-past inhalation exposure chamber system for one month. Phosphopeptides eluted from nuclear proteins of the tobacco exposured mice lungs were identified by mass spectrometry. The result showed that 77 phosphoproteins were totally identified. Among them, the semiquantitative analysis using ProteoIQ proteomic software revealed that five phosphoproteins showed the different expression patterns between control and tobacco exposure groups. Furthermore, the classification by biological functions of the identified proteins revealed that these proteins were related to inflammation, regeneration, repair, proliferation, differentiation, morphological change and nicotine or stress response. Finally, we founded advanced glycosylation end product-specific receptor (RAGE) and serine/threonine-protein kinase SNF1-like kinase 2 (SIK2) as novel smoking markers. |
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| 書誌情報 |
Journal of Bioanalysis & Biomedicine 巻 8, 号 1, p. 9-16, 発行年 2016-05-05 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.4172/1948-593X.1000146 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 659550 bytes | ||||||
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| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 498 | |||||
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| 出版者 | OMICS International | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
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| 関連タイプ | hasPart | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.omicsonline.org/open-access/nuclear-phosphoproteomics-features-the-novel-smoking-markers-inmouse-lung-tissue-following-subacute-phase-exposure-to-tobaccosmoke-1948-593X-1000146.php?aid=68843 | |||||
