WEKO3
アイテム
NGF-dependent neurons and neurobiology of emotions and feelings : Lessons from congenital insensitivity to pain with anhidrosis
http://hdl.handle.net/2298/39781
http://hdl.handle.net/2298/3978133c266bf-4ed9-4a54-998c-6def19e550e9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
NBR87_1-16.pdf (1.3 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-05 | |||||
| タイトル | ||||||
| タイトル | NGF-dependent neurons and neurobiology of emotions and feelings : Lessons from congenital insensitivity to pain with anhidrosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Allostasis, Congenital insensitivity to pain with anhidrosis, Emotion, Feeling, Homeostasis, Inflammation, Interoception, Nerve growth factor (NGF), NGF-dependent neurons, NGF-dependent primary afferent neurons, NTRK1 gene, Receptor tyrosine kinase for NGF, Stress, Sympathetic postganglionic neurons, TrkA receptor | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Indo, Yasuhiro
× Indo, Yasuhiro |
|||||
| 別言語の著者 |
犬童, 康弘
× 犬童, 康弘 |
|||||
| 内容記述 | ||||||
| 内容記述 | NGF is a well-studied neurotrophic factor, and TrkA is a receptor tyrosine kinase for NGF. The NGF-TrkA system supports the survival and maintenance of NGF-dependent neurons during development. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder due to loss-of-function mutations in the NTRKI gene encoding TrkA. Individuals with CIPA lack NGF-dependent neurons, including NGF-dependent primary afferents and sympathetic postganglionic neurons, in otherwise intact systems. Thus, the pathophysiology of CIPA can provide intriguing findings to elucidate the unique functions that NGF-dependent neurons serve in humans, which might be difficult to evaluate in animal studies. Preceding studies have shown that the NGF-TrkA system plays critical roles in pain, itching and inflammation. This review focuses on the clinical and neurobiogical aspects of CIPA and explains that NGF-dependent neurons in the peripheral nervous system play pivotal roles in interoception and homeostasis of our body, as well as in the stress response. Furthermore, these NGF-dependent neurons are likely requisite for neurobiological processes of 'emotions and feelings' in our species. | |||||
| 書誌情報 |
Neuroscience & Biobehavioral Reviews 巻 87, p. 1-16, 発行年 2018-04 |
|||||
| ISSN | ||||||
| 収録物識別子 | 01497634 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | https://doi.org/10.1016/j.neubiorev.2018.01.013 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 1287734 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.17 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | https://www.sciencedirect.com/science/article/pii/S0149763417307121?via%3Dihub | |||||
| コメント | ||||||
| Gold Open Access | ||||||
