WEKO3
アイテム
{"_buckets": {"deposit": "c0e4e86a-6d10-4aa1-8735-adbcf279055a"}, "_deposit": {"created_by": 1, "id": "22635", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "22635"}, "status": "published"}, "_oai": {"id": "oai:kumadai.repo.nii.ac.jp:00022635", "sets": ["416"]}, "author_link": ["98308", "98296", "98307", "98295", "98305", "98297", "98306", "158098"], "item_16_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-08-21", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "959", "bibliographicPageStart": "953", "bibliographicVolumeNumber": "65", "bibliographic_titles": [{"bibliographic_title": "Cancer Chemotherapy and Pharmacology"}]}]}, "item_16_creator_3": {"attribute_name": "別言語の著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "濱田, 哲暢", "creatorNameLang": "ja"}, {"creatorName": "ハマダ, アキノブ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Hamada, Akinobu", "creatorNameLang": "en"}], "familyNames": [{"familyName": "濱田", "familyNameLang": "ja"}, {"familyName": "ハマダ", "familyNameLang": "ja-Kana"}, {"familyName": "Hamada", "familyNameLang": "en"}], "givenNames": [{"givenName": "哲暢", "givenNameLang": "ja"}, {"givenName": "アキノブ", "givenNameLang": "ja-Kana"}, {"givenName": "Akinobu", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "98305", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "實松, 絵美子", "creatorNameLang": ""}, {"creatorName": "サネマツ, エミコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sanematsu, Emiko", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "實松", "familyNameLang": ""}, {"familyName": "サネマツ", "familyNameLang": "ja-Kana"}, {"familyName": "Sanematsu", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "絵美子", "givenNameLang": ""}, {"givenName": "エミコ", "givenNameLang": "ja-Kana"}, {"givenName": "Emiko", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "98306", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "齋藤, 秀之", "creatorNameLang": "ja"}, {"creatorName": "サイトウ, ヒデユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Saito, Hideyuki", "creatorNameLang": "en"}], "familyNames": [{"familyName": "齋藤", "familyNameLang": "ja"}, {"familyName": "サイトウ", "familyNameLang": "ja-Kana"}, {"familyName": "Saito", "familyNameLang": "en"}], "givenNames": [{"givenName": "秀之", "givenNameLang": "ja"}, {"givenName": "ヒデユキ", "givenNameLang": "ja-Kana"}, {"givenName": "Hideyuki", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "98307", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "佐々木, 治一郎", "creatorNameLang": "ja"}, {"creatorName": "ササキ, ジイチロウ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sasaki, Jiichiro", "creatorNameLang": "en"}], "familyNames": [{"familyName": "佐々木", "familyNameLang": "ja"}, {"familyName": "ササキ", "familyNameLang": "ja-Kana"}, {"familyName": "Sasaki", "familyNameLang": "en"}], "givenNames": [{"givenName": "治一郎", "givenNameLang": "ja"}, {"givenName": "ジイチロウ", "givenNameLang": "ja-Kana"}, {"givenName": "Jiichiro", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "98308", "nameIdentifierScheme": "WEKO"}]}]}, "item_16_description_17": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_16_description_46": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "論文(Article)", "subitem_description_type": "Other"}]}, "item_16_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "PURPOSE: This study examined the pharmacokinetics of irinotecan (CPT-11), active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), SN-38 glucuronide (SN-38G) amrubicin (AMR), and active metabolite amrubicinol (AMR-OH) after intravenous administration of this combination therapy in rats. METHODS: Male Sprague-Dawley rats were treated with 10 mg/kg CPT-11 with 10 mg/kg AMR. AMR, AMR-OH, CPT-11, SN-38 and SN-38G were measured in plasma, bile, and tissues using high-performance liquid chromatography. RESULTS: Co-administration of CPT-11 resulted in a significant decrease in plasma concentrations and area under the curves (AUC) of AMR-OH compared with treatment with AMR alone. On the other hand, co-administration of AMR resulted in a slight increase in the initial plasma concentration of SN-38; however, there were no differences in AUC values in CPT-11 and SN-38. The cumulative biliary excretion curves of AMR, CPT-11, and their active metabolites were not changed. CPT-11 inhibited the conversion of AMR to AMR-OH in rat cytosolic fractions. CONCLUSIONS: CPT-11 did not affect the pharmacokinetic of AMR but decreased the plasma concentration of AMR-OH and might affect the formation of AMR-OH from AMR in hepatocytes.", "subitem_description_type": "Other"}]}, "item_16_description_77": {"attribute_name": "URL", "attribute_value_mlt": [{"subitem_description": "http://www.springerlink.com/content/t57238162t5740n8/fulltext.html", "subitem_description_type": "Other"}]}, "item_16_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Berlin"}]}, "item_16_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s00280-009-1102-x", "subitem_relation_type_select": "DOI"}}]}, "item_16_relation_16": {"attribute_name": "情報源(ISSN)", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "03445704"}]}]}, "item_16_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© Springer-Verlag 2009"}]}, "item_16_subject_20": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "499", "subitem_subject_scheme": "NDC"}]}, "item_16_text_18": {"attribute_name": "形態", "attribute_value_mlt": [{"subitem_text_value": "248167 bytes"}]}, "item_16_text_47": {"attribute_name": "資源タイプ・ローカル", "attribute_value_mlt": [{"subitem_text_value": "雑誌掲載論文"}]}, "item_16_text_48": {"attribute_name": "資源タイプ・NII", "attribute_value_mlt": [{"subitem_text_value": "Journal Article"}]}, "item_16_text_49": {"attribute_name": "資源タイプ・DCMI", "attribute_value_mlt": [{"subitem_text_value": "text"}]}, "item_16_text_50": {"attribute_name": "資源タイプ・ローカル表示コード", "attribute_value_mlt": [{"subitem_text_value": "01"}]}, "item_16_text_76": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_text_value": "http://hdl.handle.net/2298/15930"}]}, "item_16_version_type_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "前田, 由紀子", "creatorNameLang": "ja"}, {"creatorName": "マエダ, ユキコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Maeda, Yukiko", "creatorNameLang": "en"}], "familyNames": [{"familyName": "前田", "familyNameLang": "ja"}, {"familyName": "マエダ", "familyNameLang": "ja-Kana"}, {"familyName": "Maeda", "familyNameLang": "en"}], "givenNames": [{"givenName": "由紀子", "givenNameLang": "ja"}, {"givenName": "ユキコ", "givenNameLang": "ja-Kana"}, {"givenName": "Yukiko", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "158098", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "濱田, 哲暢", "creatorNameLang": "ja"}, {"creatorName": "ハマダ, アキノブ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Hamada, Akinobu", "creatorNameLang": "en"}], "familyNames": [{"familyName": "濱田", "familyNameLang": "ja"}, {"familyName": "ハマダ", "familyNameLang": "ja-Kana"}, {"familyName": "Hamada", "familyNameLang": "en"}], "givenNames": [{"givenName": "哲暢", "givenNameLang": "ja"}, {"givenName": "アキノブ", "givenNameLang": "ja-Kana"}, {"givenName": "Akinobu", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "98305", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "實松, 絵美子", "creatorNameLang": ""}, {"creatorName": "サネマツ, エミコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sanematsu, Emiko", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "實松", "familyNameLang": ""}, {"familyName": "サネマツ", "familyNameLang": "ja-Kana"}, {"familyName": "Sanematsu", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "絵美子", "givenNameLang": ""}, {"givenName": "エミコ", "givenNameLang": "ja-Kana"}, {"givenName": "Emiko", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "98306", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "佐々木, 治一郎", "creatorNameLang": "ja"}, {"creatorName": "ササキ, ジイチロウ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sasaki, Jiichiro", "creatorNameLang": "en"}], "familyNames": [{"familyName": "佐々木", "familyNameLang": "ja"}, {"familyName": "ササキ", "familyNameLang": "ja-Kana"}, {"familyName": "Sasaki", "familyNameLang": "en"}], "givenNames": [{"givenName": "治一郎", "givenNameLang": "ja"}, {"givenName": "ジイチロウ", "givenNameLang": "ja-Kana"}, {"givenName": "Jiichiro", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "98308", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoo, Koji"}], "nameIdentifiers": [{"nameIdentifier": "98295", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hira, Asumi"}], "nameIdentifiers": [{"nameIdentifier": "98296", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Hideyuki"}], "nameIdentifiers": [{"nameIdentifier": "98297", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CCP-MAEDA20090821_r.pdf", "filesize": [{"value": "248.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 248200.0, "url": {"label": "CCP-MAEDA20090821_r.pdf", "url": "https://kumadai.repo.nii.ac.jp/record/22635/files/CCP-MAEDA20090821_r.pdf"}, "version_id": "23ee0024-bfc7-418b-be9c-db0cc5f98634"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Amrubicin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Amrubicinol", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Irinotecan", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Drug–drug interaction", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats"}]}, "item_type_id": "16", "owner": "1", "path": ["416"], "permalink_uri": "http://hdl.handle.net/2298/15930", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-09-06"}, "publish_date": "2010-09-06", "publish_status": "0", "recid": "22635", "relation": {}, "relation_version_is_last": true, "title": ["Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats"], "weko_shared_id": -1}
Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats
http://hdl.handle.net/2298/15930
http://hdl.handle.net/2298/159305758728f-155d-4cd7-baa1-a80e3fe98566
名前 / ファイル | ライセンス | アクション |
---|---|---|
CCP-MAEDA20090821_r.pdf (248.2 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2010-09-06 | |||||
タイトル | ||||||
タイトル | Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Amrubicin, Amrubicinol, Irinotecan, Drug–drug interaction | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
前田, 由紀子
× 前田, 由紀子× 濱田, 哲暢× 實松, 絵美子× 佐々木, 治一郎× Yokoo, Koji× Hira, Asumi× Saito, Hideyuki |
|||||
別言語の著者 |
濱田, 哲暢
× 濱田, 哲暢× 實松, 絵美子× 齋藤, 秀之× 佐々木, 治一郎 |
|||||
内容記述 | ||||||
内容記述 | PURPOSE: This study examined the pharmacokinetics of irinotecan (CPT-11), active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), SN-38 glucuronide (SN-38G) amrubicin (AMR), and active metabolite amrubicinol (AMR-OH) after intravenous administration of this combination therapy in rats. METHODS: Male Sprague-Dawley rats were treated with 10 mg/kg CPT-11 with 10 mg/kg AMR. AMR, AMR-OH, CPT-11, SN-38 and SN-38G were measured in plasma, bile, and tissues using high-performance liquid chromatography. RESULTS: Co-administration of CPT-11 resulted in a significant decrease in plasma concentrations and area under the curves (AUC) of AMR-OH compared with treatment with AMR alone. On the other hand, co-administration of AMR resulted in a slight increase in the initial plasma concentration of SN-38; however, there were no differences in AUC values in CPT-11 and SN-38. The cumulative biliary excretion curves of AMR, CPT-11, and their active metabolites were not changed. CPT-11 inhibited the conversion of AMR to AMR-OH in rat cytosolic fractions. CONCLUSIONS: CPT-11 did not affect the pharmacokinetic of AMR but decreased the plasma concentration of AMR-OH and might affect the formation of AMR-OH from AMR in hepatocytes. | |||||
書誌情報 |
Cancer Chemotherapy and Pharmacology 巻 65, p. 953-959, 発行年 2009-08-21 |
|||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1007/s00280-009-1102-x | |||||
権利 | ||||||
権利情報 | © Springer-Verlag 2009 | |||||
情報源(ISSN) | ||||||
関連名称 | 03445704 | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
248167 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 499 | |||||
出版者 | ||||||
出版者 | Springer Berlin | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://www.springerlink.com/content/t57238162t5740n8/fulltext.html |