| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-09-06 |
| タイトル |
|
|
タイトル |
Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Amrubicin, Amrubicinol, Irinotecan, Drug–drug interaction |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
前田, 由紀子
濱田, 哲暢
實松, 絵美子
佐々木, 治一郎
Yokoo, Koji
Hira, Asumi
齋藤, 秀之
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
PURPOSE: This study examined the pharmacokinetics of irinotecan (CPT-11), active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), SN-38 glucuronide (SN-38G) amrubicin (AMR), and active metabolite amrubicinol (AMR-OH) after intravenous administration of this combination therapy in rats. METHODS: Male Sprague-Dawley rats were treated with 10 mg/kg CPT-11 with 10 mg/kg AMR. AMR, AMR-OH, CPT-11, SN-38 and SN-38G were measured in plasma, bile, and tissues using high-performance liquid chromatography. RESULTS: Co-administration of CPT-11 resulted in a significant decrease in plasma concentrations and area under the curves (AUC) of AMR-OH compared with treatment with AMR alone. On the other hand, co-administration of AMR resulted in a slight increase in the initial plasma concentration of SN-38; however, there were no differences in AUC values in CPT-11 and SN-38. The cumulative biliary excretion curves of AMR, CPT-11, and their active metabolites were not changed. CPT-11 inhibited the conversion of AMR to AMR-OH in rat cytosolic fractions. CONCLUSIONS: CPT-11 did not affect the pharmacokinetic of AMR but decreased the plasma concentration of AMR-OH and might affect the formation of AMR-OH from AMR in hepatocytes. |
| bibliographic_information |
en : Cancer Chemotherapy and Pharmacology
巻 65,
p. 953-959,
発行年 2009-08-21
|
| item_16_source_id_7 |
|
|
収録物識別子 |
0344-5704 |
| 権利 |
|
|
権利情報 |
(C) Springer-Verlag 2009 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
499 |
| 出版者 |
|
|
出版者 |
Springer Berlin |
| 関連 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s00280-009-1102-x |
CCP-MAEDA20090821_r.pdf (248.2 kB)
