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[18F] 酢酸の標識合成と分取精製 (臨床応用への基礎実験)
http://hdl.handle.net/2298/24603
http://hdl.handle.net/2298/24603d7aa8b3f-7748-4805-887c-0090b1ba84e2
名前 / ファイル | ライセンス | アクション |
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MH0008_071-076.pdf (730.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2012-05-16 | |||||
タイトル | ||||||
タイトル | [18F] 酢酸の標識合成と分取精製 (臨床応用への基礎実験) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 18F-Acetate, Synthesis, Solvent extraction, Radiochemical yield, Pyrogen test | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
宮崎, 吉博
× 宮崎, 吉博× 二宮, 賢太郎× 竹永, 枝里子× 山野, 正起× 盛島, 由貴× 野守, 裕明× 冨吉, 勝美 |
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別言語の著者 |
宮崎, 吉博
× 宮崎, 吉博× Ninomiya, Kentaro× Takenaga, Eriko× Yamano, Masaki× Morishima, Yoshitaka× Nomori, Hiroaki× 冨吉, 勝美 |
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内容記述 | ||||||
内容記述 | 18F-Acetate (18F-Ace) was synthesized by a simple and quick halogen phase exchange catalysis. solvent extraction method was employed to purify 18F-Ace directly from the reaction vessel. These all simple synthesis and purification method make reactions short and quick so that all synthesis time takes less than 30 minutes. 2- Iodo-acetic ethylester (ICH2COOC2H5) dissolved in anhydrous acetylnirile reacted with 18F-fluorine in Kriptfix-222 and produce 2-18F-acetic ethylester in acetylinitrile. Final product 18F-Ace was obtained by hydrolysis of 2-18F-acetic ethylester in 0.25N NaOH. 18F-Actate radiochemical yield was 48.7% ± 5.2% (n-5). Pyrogen test and sterility check were all negative. With these new simple synthesis and quick purification. 18F-Ace will be more employed to diagnose tumors such as well differentiate one then 18FDG. | |||||
書誌情報 |
熊本大学医学部保健学科紀要 巻 8, p. 71-76, 発行年 2012-03-30 |
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ISSN | ||||||
収録物識別子 | 18807151 | |||||
NCID | ||||||
収録物識別子 | AA12010572 | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
730396 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 437.5 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | A simple 18F-Acetate Synthesis and Purification and Quality Control for Clinical Use | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | 18F サクサン ノ ヒョウシキ ゴウセイ ト ブンシュ セイセイ リンショウ オウヨウ エノ キソジッケン | |||||
出版者 | ||||||
出版者 | 熊本大学 | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
紀要論文 | ||||||
資源タイプ・NII | ||||||
Departmental Bulletin Paper | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
02 |