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Hyperthermia with Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis
http://hdl.handle.net/2298/29211
http://hdl.handle.net/2298/29211ad774ea5-11dc-4ab8-93ba-33fee91a8d9c
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Figures-1.pdf (745.1 kB)
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Supplemental data for Diabetes _Kondo et al_-2.pdf (1.0 MB)
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MET-beta for Diabetes _Kondo et al_ -clean copy-1.pdf (149.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-01-29 | |||||
タイトル | ||||||
タイトル | Hyperthermia with Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Kondo, Tatsuya
× Kondo, Tatsuya× 佐々木, 一成× Matsuyama, Rina× 古賀, 沙緒里× Adachi, Hironori× Suico, Mary A× Kawashima, Junji× Motoshima, Hiroyuki× Furukawa, Noboru× Kai, Hirofumi× 荒木, 栄一 |
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別言語の著者 |
近藤, 龍也
× 近藤, 龍也× 佐々木, 一成× 松山, 利奈× 古賀, 沙緒里× 足立, 博紀× 河島, 淳司× 本島, 寛之× 古川, 昇× 甲斐, 広文× 荒木, 栄一 |
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内容記述 | ||||||
内容記述 | Induction of heat shock protein (HSP) 72 improves metabolic profiles in diabetic model mice. However, its impact on pancreatic β-cells is not known. The present study investigated whether HSP72 induction can reduce β-cell stress signaling and apoptosis, and preserve β-cell mass. MIN6 cells and db/db mice were sham-treated or treated with heat shock (HS) + mild electrical stimulation (MES) to induce HSP72. Several cellular markers, metabolic parameters and β-cell mass were evaluated. HS+MES treatment or HSP72 overexpression increased the HSP72 protein levels and decreased TNF-β-induced JNK phosphorylation, ER stress and pro-apoptotic signal in MIN6 cells. In db/db mice, HS+MES treatment for 12 weeks significantly improved the insulin sensitivity and glucose homeostasis. Upon glucose challenge, a significant increase in insulin secretion was observed in vivo. Compared with sham treatment, the HSP72, insulin, PDX-1, GLUT2 and IRS-2 levels were upregulated in the pancreatic islets of HS+MES-treated mice, whereas JNK phosphorylation, nuclear translocation of FOXO1 and NF-βB p65 were reduced. Apoptotic signals, ER stress and oxidative stress markers were attenuated. Thus, HSP72 induction by HS+MES treatment protects β-cells from apoptosis by attenuating JNK activation and cell stresses. HS+MES combination therapy may preserve pancreatic β-cell volume to ameliorate glucose homeostasis in diabetes. |
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書誌情報 |
Diabetes 巻 61, 号 4, p. 838-847, 発行年 2012-04 |
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ISSN | ||||||
収録物識別子 | 00121797 | |||||
書誌レコードID | ||||||
収録物識別子 | AA00628057 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 22362176 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.2337/db11-1098 | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
149840 bytes | ||||||
形態 | ||||||
1043158 bytes | ||||||
形態 | ||||||
745068 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 493 | |||||
出版者 | ||||||
出版者 | American Diabetes Association | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://diabetes.diabetesjournals.org/content/61/4/838.abstract |