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Hyperthermia with Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis
http://hdl.handle.net/2298/29211
http://hdl.handle.net/2298/29211ad774ea5-11dc-4ab8-93ba-33fee91a8d9c
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Figures-1.pdf (745.1 kB)
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Supplemental data for Diabetes _Kondo et al_-2.pdf (1.0 MB)
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MET-beta for Diabetes _Kondo et al_ -clean copy-1.pdf (149.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-01-29 | |||||
| タイトル | ||||||
| タイトル | Hyperthermia with Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kondo, Tatsuya
× Kondo, Tatsuya× 佐々木, 一成× Matsuyama, Rina× 古賀, 沙緒里× Adachi, Hironori× Suico, Mary A× Kawashima, Junji× Motoshima, Hiroyuki× Furukawa, Noboru× Kai, Hirofumi× 荒木, 栄一 |
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| 別言語の著者 |
近藤, 龍也
× 近藤, 龍也× 佐々木, 一成× 松山, 利奈× 古賀, 沙緒里× 足立, 博紀× 河島, 淳司× 本島, 寛之× 古川, 昇× 甲斐, 広文× 荒木, 栄一 |
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| 内容記述 | ||||||
| 内容記述 | Induction of heat shock protein (HSP) 72 improves metabolic profiles in diabetic model mice. However, its impact on pancreatic β-cells is not known. The present study investigated whether HSP72 induction can reduce β-cell stress signaling and apoptosis, and preserve β-cell mass. MIN6 cells and db/db mice were sham-treated or treated with heat shock (HS) + mild electrical stimulation (MES) to induce HSP72. Several cellular markers, metabolic parameters and β-cell mass were evaluated. HS+MES treatment or HSP72 overexpression increased the HSP72 protein levels and decreased TNF-β-induced JNK phosphorylation, ER stress and pro-apoptotic signal in MIN6 cells. In db/db mice, HS+MES treatment for 12 weeks significantly improved the insulin sensitivity and glucose homeostasis. Upon glucose challenge, a significant increase in insulin secretion was observed in vivo. Compared with sham treatment, the HSP72, insulin, PDX-1, GLUT2 and IRS-2 levels were upregulated in the pancreatic islets of HS+MES-treated mice, whereas JNK phosphorylation, nuclear translocation of FOXO1 and NF-βB p65 were reduced. Apoptotic signals, ER stress and oxidative stress markers were attenuated. Thus, HSP72 induction by HS+MES treatment protects β-cells from apoptosis by attenuating JNK activation and cell stresses. HS+MES combination therapy may preserve pancreatic β-cell volume to ameliorate glucose homeostasis in diabetes. |
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| 書誌情報 |
Diabetes 巻 61, 号 4, p. 838-847, 発行年 2012-04 |
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| ISSN | ||||||
| 収録物識別子 | 00121797 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00628057 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 22362176 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.2337/db11-1098 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 149840 bytes | ||||||
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| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
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| 出版者 | American Diabetes Association | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://diabetes.diabetesjournals.org/content/61/4/838.abstract | |||||
