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Nerve growth factor, interoception, and sympathetic neuron: Lesson from congenital insensitivity to pain with anhidrosis
http://hdl.handle.net/2298/11429
http://hdl.handle.net/2298/114296243b6a2-e2d3-458c-b336-4bbe30315f20
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN-09YI.pdf (172.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-04-30 | |||||
| タイトル | ||||||
| タイトル | Nerve growth factor, interoception, and sympathetic neuron: Lesson from congenital insensitivity to pain with anhidrosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Nerve growth factor (NGF), 神経成長因子, Receptor tyrosine kinase for NGF, チロシンキナーゼ型神経成長因子受容体, TrkA protein, TrkA タンパク質, NTRK1 gene, NTRK1 遺伝子, TRKA gene, TRKA 遺伝子, Congenital insensitivity to pain with anhidrosis, 先天性無痛無汗症, Interoception, 内感覚, Polymodal receptor, ポリモーダル受容器, Sympathetic neuron, 交感神経ニューロン, Basal forebrain cholinergic neuron, 前脳基底野コリン作動性ニューロン, Emotion, 情動, Pain, 痛み, 疼痛, Homeostasis, 恒常性, Hereditary sensory and autonomic neuropathy type IV, 遺伝性感覚自律神経性ニュー ロパシー IV 型 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
犬童, 康弘
× 犬童, 康弘 |
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| 別言語の著者 |
Indo, Yasuhiro
× Indo, Yasuhiro |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and maintenance of sensory and sympathetic neurons. Congenital insensitivity to pain with anhidrosis (CIPA) is a genetic disorder due to loss-of-function mutations in the NTRK1 (also known as TRKA) gene encoding TrkA, a receptor tyrosine kinase for NGF. Patients with CIPA provide us a rare opportunity to explore the developmental and physiological function of the NGF-dependent neurons in behavior, cognitive, and mental activities that are not available in animal studies. Here, I discuss the significance of findings that patients with CIPA lack NGF-dependent neurons, including interoceptive polymodal receptors, sympathetic postganglionic neurons, and probably several types of neurons in the brain. They also exhibit characteristic emotional behavior or problems. Together, the NGF-TrkA system is essential for the establishment of a neural network for interoception and homeostasis that may underlie 'gut feelings'. Thus, NGF-dependent neurons play a crucial role in emotional experiences and decision-making processes. Prospective studies focused on these neurons might provide further insights into the neural basis of human emotion and feeling. | |||||
| 書誌情報 |
Autonomic neuroscience: basic & clinical 巻 147, 号 1-2, p. 3-8, 発行年 2009-05 |
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| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11470577 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.autneu.2009.01.008 | |||||
| 権利 | ||||||
| 権利情報 | Elsevier B.V. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 15660702 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 172471 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier B.V. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
