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Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
http://hdl.handle.net/2298/16910
http://hdl.handle.net/2298/16910e6b9db45-bacd-4077-a7e8-81ca380f3062
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BMCL20_11_3341-3343.pdf (203.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2010-11-18 | |||||
| タイトル | ||||||
| タイトル | Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | proteasome, chymotrypsin-like activity, sponge, alkaloid | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukamoto, Sachiko
× Tsukamoto, Sachiko× Yamanokuchi, Rumi× Yoshitomi, Makiko× Sato, Kohei× Ikeda, Tsuyoshi× Rotinsulu, Henki× E. P. Mangindaan, Remy× J. de Voogd, Nicole× W. M. van Soest, Rob× Yokosawa, Hideyoshi |
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| 抄録 | ||||||
| 内容記述 | Aaptamine (1), isoaaptamine (2), and demethylaaptamine (3) were isolated from the marine sponge Aaptos suberitoides collected in Indonesia as inhibitors of the proteasome. They inhibited the chymotrypsin-like and caspase-like activities of the proteasome with IC50 values of 1.6-4.6 μg/mL, while they showed less inhibition of the trypsin-like activity of the proteasome. The three compounds showed cytotoxic activities against HeLa cells, but their cytotoxicity did not correlate with their potency as proteasome inhibitors, strongly suggesting that their proteasomal inhibitory activity is dispensable to their cytotoxicity. | |||||
| 書誌情報 |
en : Bioorganic and Medicinal Chemistry Letters 巻 20, 号 11, p. 3341-3343, 発行年 2010-06-01 |
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| ISSN | ||||||
| 収録物識別子 | 0960-894X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.bmcl.2010.04.029 | |||||
| 権利 | ||||||
| 権利情報 | (C) Copyright 2010 Elsevier B.V. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier BV | |||||
