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Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test
http://hdl.handle.net/2298/18939
http://hdl.handle.net/2298/18939698f9e8d-5077-423a-b1f9-342a99875b22
| 名前 / ファイル | ライセンス | アクション |
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EJP_651_1-3_Fig1-3.pdf (27.7 kB)
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EJP_651_1-3_106-108.pdf (178.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-05-19 | |||||
| タイトル | ||||||
| タイトル | Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Antinociceptive-like action, Antitussives; Carbamazepine, G-protein coupled inwardly rectifying potassium ion channels, Tipepidine | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
川浦, 一晃
× 川浦, 一晃× 三木, 理沙× Urashima, Yuri× 本田, 宗吉× M. Shehata, Ahmed× 副田, 二三夫× 白崎, 哲哉× 高濱, 和夫 |
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| 別言語の著者 |
川浦, 一晃
× 川浦, 一晃× 三木, 理沙× 浦嶋, 優里× 本田, 宗吉× 副田, 二三夫× 白崎, 哲哉× 高濱, 和夫 |
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| 内容記述 | ||||||
| 内容記述 | Several antidepressants have been used to treat severe pain in clinics. Recently, we reported that the centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test, although the mechanism of action appears to be quite different from that of known antidepressants. In the present study, we investigated whether a combination of tipepidine and carbamazepine acts synergistically to induce an antinociceptive effect in the acetic acid-induced writhing test in mice. Prior to studying the combination of tipepidine and carbamazepine, the analgesic action of tipepidine alone was also examined in mice. Tipepidine at 5–40 mg/kg i.p. significantly reduced the number of writhes induced by acetic acid in mice. Carbamazepine at 20 mg/kg i.p. also significantly reduced the writhing reaction. Furthermore, co-administration of carbamazepine (5 and 10 mg/kg, i.p.) and tipepidine (2.5 mg/kg i.p.) significantly decreased the number of writhes induced by acetic acid. This finding suggests that a combination of carbamazepine and tipepidine may be a new strategy for the treatment of neuropathic pain such as what occurs in trigeminal neuralgia, because the use of carbamazepine is often limited by its adverse effects and by reduction of its analgesic efficacy by microsomal enzyme induction. |
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| 書誌情報 |
European Journal of Pharmacology 巻 651, 号 1-3, p. 106-108, 発行年 2011-01-25 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21114989 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.ejphar.2010.10.086 | |||||
| 権利 | ||||||
| 権利情報 | © 2010 Elsevier B.V. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 00142999 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 178791 bytes | ||||||
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| 27713 bytes | ||||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.5 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier B.V. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
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| Journal Article | ||||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1J-51JXFP1-S&_user=4545557&_coverDate=01%2F25%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=8b9435572e26660fc145da2e40e62499&searchtype=a | |||||
