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Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo.
http://hdl.handle.net/2298/19078
http://hdl.handle.net/2298/19078c9dffeb3-60a0-4e6f-bf55-69b6c4ee8beb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Blood 2010_28335.pdf (3.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-05-27 | |||||
| タイトル | ||||||
| タイトル | Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
小原, 恭子
× 小原, 恭子× 笠間, 由里× Sekiguchi, Satoshi× Saito, Makoto× 田中, 康介× Satoh, Masaaki× Kuwahara, Kazuhiko× 阪口, 薫雄× 竹屋, 元裕× Hiasa, Yoichi× Kohara, Michinori× 小原, 恭子 |
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| 別言語の著者 |
小原 恭子
× 小原 恭子× 笠間, 由里× 関口, 敏× 齊藤, 誠× 田中, 康介× 佐藤, 正明× 桑原, 一彦× 阪口, 薫雄× 竹屋, 元裕× 日浅, 陽一× 小原, 道法 |
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| 内容記述 | ||||||
| 内容記述 | Extrahepatic manifestations of hepatitis C virus (HCV) infection have been reported in 40–70% of HCV-infected patients. B-cell non-Hodgkin’s lymphoma is a typical extrahepatic manifestation frequently associated with HCV infection. Although the HCV infection of B cells has been reported, the mechanism of disease onset remains unclear. In this study we established HCV transgenic mice that express the full HCV genome in B cells (RzCD19Cre mice) and observed a 25.0% incidence of non-Hodgkin’s diffuse large B-cell lymphomas (22.2% in males and 25.9% in females) within 600 days after birth. Expression levels of aspartate aminotransferase, alanine aminotransferase, and 32 different cytokines, chemokines and growth factors were examined. The incidence of B-cell lymphoma was significantly correlated with only the level of soluble interleukin-2 receptor ! subunit (sIL-2R!) in RzCD19Cre mouse serum. All RzCD19Cre mice with substantially elevated serum sIL-2Rα levels (>1,000 pg/mL) developed B-cell lymphomas. Moreover, compared to tissues from control animals, the B-cell lymphoma tissues of RzCD19Cre mice expressed significantly higher levels of IL-2Rα. We show that the expression of HCV in B cells promotes non-Hodgkin’s-type diffuse B-cell lymphoma, and therefore, the RzCD19Cre mouse is a powerful model to study the mechanisms related to the development of HCV-associated B-cell lymphoma. |
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| 書誌情報 |
Blood 巻 116, 号 23, p. 4926-4933, 発行年 2010-12-02 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20733156 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1182/blood-2010-05-283358 | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 00064971 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 3153425 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.87 | |||||
| 出版者 | ||||||
| 出版者 | American Society of Hematology | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://bloodjournal.hematologylibrary.org/content/116/23/4926 | |||||
