| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2011-07-08 |
| タイトル |
|
|
タイトル |
CDKインヒビターによるアポトーシス制御 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
CDK インヒビター ニ ヨル アポトーシス セイギョ |
|
言語 |
ja-Kana |
| タイトル |
|
|
タイトル |
Cyclin-dependent kinase inhibitors in the regulation of apoptosis |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
主題 |
Cell cycle, Cyclin, Cyclin-depedent kinase, p27, p21, Apoptosis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
梶原, 隆太郎
福重, 翔太
田邊, 香野
乾, 誠治
|
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell cycle progression towards S phase and later to initiate mitosis. Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors. The identification of new targets of Cip/Kip proteins as well as evidence of Cip/Kip cytoplasmic relocalization have revealed unexpected functions of these proteins in the regulation of apoptosis. This article discusses recent insights into this possible additional functions of p21 and p27. |
| 書誌情報 |
ja : 熊本大学医学部保健学科紀要
巻 7,
p. 1-9,
発行年 2011-03-23
|
| ISSN |
|
|
収録物識別子 |
1880-7151 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12010572 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
463.6 |
| 出版者 |
|
|
出版者 |
熊本大学 |
|
言語 |
ja |
MH0007_001-0009.pdf (1.5 MB)
