WEKO3
アイテム
{"_buckets": {"deposit": "909be195-8afd-456d-9f03-559343168fdb"}, "_deposit": {"created_by": 12, "id": "24891", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "24891"}, "status": "published"}, "_oai": {"id": "oai:kumadai.repo.nii.ac.jp:00024891", "sets": ["414"]}, "author_link": ["157885", "157886", "157887", "157888"], "item_15_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-03-23", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "9", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "熊本大学医学部保健学科紀要", "bibliographic_titleLang": "ja"}]}]}, "item_15_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell cycle progression towards S phase and later to initiate mitosis. Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors. The identification of new targets of Cip/Kip proteins as well as evidence of Cip/Kip cytoplasmic relocalization have revealed unexpected functions of these proteins in the regulation of apoptosis. This article discusses recent insights into this possible additional functions of p21 and p27.", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_15_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "熊本大学", "subitem_publisher_language": "ja"}]}, "item_15_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1880-7151", "subitem_source_identifier_type": "PISSN"}]}, "item_15_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12010572", "subitem_source_identifier_type": "NCID"}]}, "item_15_subject_20": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "463.6", "subitem_subject_scheme": "NDC"}]}, "item_15_version_type_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "梶原, 隆太郎", "creatorNameLang": "ja"}, {"creatorName": "カジハラ, リュウタロウ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Kajihara, Ryutaro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "157885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福重, 翔太", "creatorNameLang": "ja"}, {"creatorName": "フクシゲ, ショウタ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Fukushige, Shota", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "157886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田邊, 香野", "creatorNameLang": "ja"}, {"creatorName": "タナベ, カノ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Tanabe, Kano", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "157887", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "乾, 誠司", "creatorNameLang": "ja"}, {"creatorName": "イヌイ, セイジ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Inui, Seiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "157888", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "MH0007_001-0009.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "MH0007_001-0009.pdf", "url": "https://kumadai.repo.nii.ac.jp/record/24891/files/MH0007_001-0009.pdf"}, "version_id": "5afa47d2-ef9f-41ad-b617-f3c88c6aeda6"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cell cycle", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cyclin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cyclin-depedent kinase", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p27", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p21", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Apoptosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "CDKインヒビターによるアポトーシス制御", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "CDKインヒビターによるアポトーシス制御", "subitem_title_language": "ja"}, {"subitem_title": "CDK インヒビター ニ ヨル アポトーシス セイギョ", "subitem_title_language": "ja-Kana"}, {"subitem_title": "Cyclin-dependent kinase inhibitors in the regulation of apoptosis", "subitem_title_language": "en"}]}, "item_type_id": "15", "owner": "12", "path": ["414", "1262"], "permalink_uri": "http://hdl.handle.net/2298/20118", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2011-07-08"}, "publish_date": "2011-07-08", "publish_status": "0", "recid": "24891", "relation": {}, "relation_version_is_last": true, "title": ["CDKインヒビターによるアポトーシス制御"], "weko_shared_id": -1}
CDKインヒビターによるアポトーシス制御
http://hdl.handle.net/2298/20118
http://hdl.handle.net/2298/20118e7f468ab-a4e0-40ec-9485-e798ab5f8575
名前 / ファイル | ライセンス | アクション |
---|---|---|
MH0007_001-0009.pdf (1.5 MB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-07-08 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | CDKインヒビターによるアポトーシス制御 | |||||
タイトル | ||||||
言語 | ja-Kana | |||||
タイトル | CDK インヒビター ニ ヨル アポトーシス セイギョ | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cyclin-dependent kinase inhibitors in the regulation of apoptosis | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | Cell cycle, Cyclin, Cyclin-depedent kinase, p27, p21, Apoptosis | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
梶原, 隆太郎
× 梶原, 隆太郎× 福重, 翔太× 田邊, 香野× 乾, 誠司 |
|||||
内容記述 | ||||||
内容記述 | Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell cycle progression towards S phase and later to initiate mitosis. Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors. The identification of new targets of Cip/Kip proteins as well as evidence of Cip/Kip cytoplasmic relocalization have revealed unexpected functions of these proteins in the regulation of apoptosis. This article discusses recent insights into this possible additional functions of p21 and p27. | |||||
書誌情報 |
ja : 熊本大学医学部保健学科紀要 巻 7, p. 1-9, 発行年 2011-03-23 |
|||||
ISSN | ||||||
収録物識別子 | 1880-7151 | |||||
NCID | ||||||
収録物識別子 | AA12010572 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
日本十進分類法 | ||||||
主題 | 463.6 | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 熊本大学 |