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Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones
http://hdl.handle.net/2298/27244
http://hdl.handle.net/2298/2724403c52727-6a67-470c-81c4-95690df25222
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-03-11 | |||||
タイトル | ||||||
タイトル | Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Carbonyl reductase activity, alkyl phenyl ketones, 4-benzoylpyridine, pig heart cytosol, substrate inhibition | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
今村, 順茂
× 今村, 順茂× Narumi, Rika× 島田, 秀昭 |
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別言語の著者 |
今村, 順茂
× 今村, 順茂× 鳴海, 里加× 島田, 秀昭 |
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内容記述 | ||||||
内容記述 | The inhibitory effects of alkyl phenyl ketones on carbonyl reductase activity were examined in pig heart. In this study, carbonyl reductase activity was estimated as the ability to reduce 4-benzoylpyridine to S(-)-α-phenyl-4-pyridylmethanol in the cytosolic fraction from pig heart (pig heart cytosol). The order of their inhibitory potencies for the enzyme activity was hexanophenone > valerophenone > heptanophenone > butyrophenone > propiophenone. The inhibitory potencies of acetophenone and nonanophenone were much lower. A significant relationship was observed between Vmax/Km values for the reduction of alkyl phenyl ketones and their inhibitory potencies for carbonyl reductase activity in pig heart cytosol. Furthermore, hexanophenone was a competitive inhibitor for the enzyme activity. These results indicate that several alkyl phenyl ketones including hexanophenone inhibit carbonyl reductase activity in pig heart cytosol, by acting as substrate inhibitors. | |||||
書誌情報 |
Journal of Enzyme Inhibition and Medicinal Chemistry 巻 22, 号 1, p. 105-109, 発行年 2007-02 |
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ISSN | ||||||
収録物識別子 | 14756366 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 17373555 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1080/14756360600954023 | |||||
権利URI | ||||||
© 2007 Informa Healthcare | ||||||
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内容記述 | application/pdf | |||||
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出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 491.45 | |||||
出版者 | ||||||
出版者 | Informa Healthcare | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
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text | ||||||
資源タイプ・ローカル表示コード | ||||||
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URL | ||||||
内容記述 | http://informahealthcare.com/doi/abs/10.1080/14756360600954023 |