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  1. 教育学
  2. 発表論文(教育)

Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation

http://hdl.handle.net/2298/27267
http://hdl.handle.net/2298/27267
c85d1b36-cdb9-446a-9b2b-6ec0d0b84191
名前 / ファイル ライセンス アクション
Fig8.pdf Fig8.pdf (8.6 kB)
Fig7.pdf Fig7.pdf (7.6 kB)
Fig6.pdf Fig6.pdf (7.6 kB)
Fig5.pdf Fig5.pdf (8.3 kB)
Fig4.pdf Fig4.pdf (7.0 kB)
Fig3.pdf Fig3.pdf (8.4 kB)
Fig2.pdf Fig2.pdf (137.9 kB)
Fig1.pdf Fig1.pdf (7.5 kB)
Toxicology.203.189-197.pdf Toxicology.203.189-197.pdf (55.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-03-13
タイトル
タイトル Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation
言語
言語 eng
キーワード
主題 Cadmium toxicity, Strain difference, Tissue accumulation, Rat
資源タイプ
資源タイプ departmental bulletin paper
著者 島田, 秀昭

× 島田, 秀昭

WEKO 78310

ja 島田, 秀昭
ISNI

en Shimada, Hideaki

ja-Kana シマダ, ヒデアキ

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Takamure, Yasutaka

× Takamure, Yasutaka

WEKO 147511

Takamure, Yasutaka

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Shimada, Akinori

× Shimada, Akinori

WEKO 147512

Shimada, Akinori

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Yasutake, Akira

× Yasutake, Akira

WEKO 147507

Yasutake, Akira

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Waalkes, Michael P.

× Waalkes, Michael P.

WEKO 147508

en Waalkes, Michael P.

ja Waalkes, Michael P.
ISNI

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今村, 順茂

× 今村, 順茂

WEKO 147196

ja 今村, 順茂
ISNI

en Imamura, Yorishige

ja-Kana イマムラ, ヨリシゲ

Search repository
別言語の著者 島田, 秀昭

× 島田, 秀昭

WEKO 78310

ja 島田, 秀昭
ISNI

en Shimada, Hideaki

ja-Kana シマダ, ヒデアキ

Search repository
高群, 泰隆

× 高群, 泰隆

WEKO 147511

高群, 泰隆

Search repository
島田, 章則

× 島田, 章則

WEKO 147512

島田, 章則

Search repository
安武, 章

× 安武, 章

WEKO 147507

安武, 章

Search repository
Waalkes, Michael P.

× Waalkes, Michael P.

WEKO 147508

en Waalkes, Michael P.

ja Waalkes, Michael P.
ISNI

Search repository
内容記述
内容記述 We previously reported that Wistar-Imamichi (WI) rats have a strong resistance to cadmium (Cd)-induced lethality compared to other strains such as Fischer 344 (Fischer) rats. The present study was designed to establish biochemical and histological differences in Cd toxicity in WI and Fischer rats, and to clarify the mechanistic basis of these strain differences. A single Cd (4.5 mg/kg, s.c.) treatment caused a significant increase in serum alanine aminotransferase activity, indicative of hepatotoxicity, in Fischer rats, but did not in WI rats. This difference in hepatotoxic response to Cd was supported by pathological analysis. After treatment with Cd at doses of 3.0, 3.5 and 4.5 mg/kg, the hepatic and renal accumulation of Cd was significantly lower in the WI rats than in the Fischer rats, indicating a kinetic mechanism for the observed strain differences in Cd toxicity. Thus, the remarkable resistance to Cd-induced hepatotoxicity in WI rats is associated, at least in part, with a lower tissue accumulation of the metal. Hepatic and renal zinc (Zn) contents after administration were similarly lower in WI than in Fischer rats. When Zn was administered in combination with Cd to Fischer rats, it decreased Cd contents in the liver and kidney, and exhibited a significant protective effect against the toxicity of Cd. We propose the possibility that Zn transporter plays an important role in the strain difference of Cd toxicity in WI and Fischer rats.
書誌情報 Toxicology

巻 203, 号 1-3, p. 189-197, 発行年 2004-10-15
ISSN
収録物識別子 0300483X
PubMed番号
関連タイプ isVersionOf
識別子タイプ PMID
関連識別子 15363594
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.tox.2004.06.012
権利
権利情報 © 2004 Elsevier Ireland Ltd
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内容記述 application/pdf
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著者版フラグ
出版タイプ AM
日本十進分類法
主題 493
出版者
出版者 Elsevier Ireland Ltd
資源タイプ
内容記述 論文(Article)
資源タイプ・ローカル
紀要論文
資源タイプ・NII
Departmental Bulletin Paper
資源タイプ・DCMI
text
資源タイプ・ローカル表示コード
02
URL
内容記述 http://www.sciencedirect.com/science/article/pii/S0300483X04003294
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