| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-01-29 |
| タイトル |
|
|
タイトル |
Accumulation of Pericardial Fat Correlates with Left Ventricular Diastolic Dysfunction in Patients with Normal Ejection Fraction |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
pericardium, obesity, diastole, heart failure |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
小西, 正紹
杉山, 正悟
菅村, 公一
野崎, 俊光
松原, 純一
秋山, 英一
宇都宮, 大輔
松澤, 泰志
山下, 康行
木村, 和生
梅村, 敏
小川, 久雄
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background Left ventricular diastolic dysfunction (LVDD) plays an important role in heart failure with normal left ventricular ejection fraction (LVEF). Obesity is one of the major comorbid conditions of LVDD. Pericardial fat (PF) is an ectopic fat depot with possible paracrine or mechanical effects on the coronary circulation and myocardial function.
Methods We measured PF volume on 64 slice computed tomography and analyzed echocardiographic parameters to confirm LVDD in 229 consecutive patients suspected of coronary artery disease with LVEF of more than 50% and no symptomatic heart failure (59% men, 67±12 years). LVDD was defined as the ratio of transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity (E/e’) >10.
Results PF volume correlated significantly with E/e’ (r=0.21, p<0.01), left ventricular mass index (r=0.23, p<0.001), and left atrial diameter (r=0.32, p<0.001). The mean PF volume was significantly greater in patients with LVDD (184±61 cm3, n=141) than in those without LVDD (154±58, n=88, p<0.001). Multivariate logistic regression analysis indicated that PF volume correlated significantly with the presence of LVDD (odds ratio: 2.00 per 100 cm3 increase in PF volume, p=0.02) independent of age, gender, abdominal obesity, hypertension, and diabetes.
Conclusions PF volumes are significantly associated with LVDD, independent of other factors such as hypertension or diabetes. PF may be implicated in the pathogenesis of LVDD in patients with normal LVEF. |
| bibliographic_information |
en : Journal of Cardiology
巻 59,
号 3,
p. 344-351,
発行年 2012-05
|
| item_16_source_id_7 |
|
|
収録物識別子 |
0914-5087 |
| item_16_source_id_9 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10070473 |
| 権利 |
|
|
権利情報 |
Japanese College of Cardiology |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
493 |
| 出版者 |
|
|
出版者 |
Japanese College of Cardiology |
| 出版者 |
|
|
出版者 |
Elsevier |
| 関連 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.jjcc.2012.01.006 |
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