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全身性アミロイドイメージングプローブ18F-EFSBの臨床応用に向けた基礎研究
http://hdl.handle.net/2298/39287
http://hdl.handle.net/2298/392873d0ac347-6b76-4bfb-ade0-ee59454b4450
名前 / ファイル | ライセンス | アクション |
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MH0014_033-041.pdf (949.3 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-03-13 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 全身性アミロイドイメージングプローブ18F-EFSBの臨床応用に向けた基礎研究 | |||||
タイトル | ||||||
言語 | ja-Kana | |||||
タイトル | ゼンシン セイ アミロイド イメージング プローブ 18F-EFSB ノ リンショウ オウヨウ ニ ムケタ キソ ケンキュウ | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Fundamental Study for Clinical Application of Systemic Amyloid Imaging Probe 18F-EFSB | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | Systemic amyloidosis, Amyloid PET, Histochemical analysis, Radiosynthesis, Quality control | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
鈴木, 涼馬
× 鈴木, 涼馬× 盛島, 由貴× 松永, 浩文× 山下, 太郎× 冨吉, 勝美 |
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内容記述 | ||||||
内容記述 | Early detection and quantitative evaluation of deposited amyloid is extremely important in treating patients with amyloidosis. we made a precursor EMSB and 19F-EFSB labeled stable isotope fluorine on EMSB to develop a new imaging probe18F-EFSB that detects systemic amyloidosis by PET examination. In this study, the following three were carried out as basic research for clinical application of 18F-EFSB for diagnosis (1)histochemical analysis to amyloid using 19F-EFSB, (2)investigation of optimal synthesis condition of 18F-EFSB, (3)quality control of 18F-EFSB. As a result of histochemical analysis, 19F-EFSB specifically accumulated in all disease type amyloid. Therefore, it was shown that 18F-EFSB also accumulates in amyloid.18F-EFSB was efficiently labeled with a radiochemical purity of 81.7 ± 5.1%(n=3) by reaction at 200 degree for 5 minutes. Quality control (radiochemical purity test, pH measurement, endotoxin test,sterility test) performed was no problem. By clearing some quality control in the future, 18F-EFSB may be a clinically applicable tracer capable of detecting amyloid in the whole body. | |||||
書誌情報 |
ja : 熊本大学医学部保健学科紀要 巻 14, p. 33-41, 発行年 2018-03-31 |
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NCID | ||||||
収録物識別子 | AA12010572 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
日本十進分類法 | ||||||
主題 | 493 | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 熊本大学 | |||||
コメント | ||||||
ja | ||||||
【著者所属】鈴木涼馬:熊本大学大学院保健学教育部 / 盛島由貴:熊本赤十字病院 / 松永浩文:熊本大学大学院薬学教育部先端生命医療科学部門 / 山下太郎:熊本大学大学院生命科学研究部脳神経科学講座神経内科学分野 / 冨吉勝美:熊本大学大学院生命科学研究部医用理工学分野 |