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The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections
http://hdl.handle.net/2298/41363
http://hdl.handle.net/2298/41363e297e417-9cdd-4d64-9ac3-372573398249
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fimmu-09-02755.pdf (419.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-01-15 | |||||
| タイトル | ||||||
| タイトル | The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | co-inhibitory receptor, HTLV-1, HIV-1, PD-1, TIGIT | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Matsuoka, Masao
× Matsuoka, Masao× Yasuma-Mitobe, Keiko |
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| 別言語の著者 |
松岡, 雅雄
× 松岡, 雅雄× 安間-水戸部, 恵子 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Costimulatory and coinhibitory receptors play a key role in regulating immune responses to infection and cancer. Coinhibitory receptors include programmed cell death 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and T cell immunoglobulin and ITIM domain (TIGIT), which suppress immune responses. Coinhibitory receptors are highly expressed on exhausted virus-specific T cells, indicating that viruses evade host immune responses through enhanced expression of these molecules. Human retroviruses, human immunodeficiency virus (HIV) and human T-cell leukemia virus type 1 (HTLV-1), infect T cells, macrophages and dendritic cells. Therefore, one needs to consider the effects of coinhibitory receptors on both uninfected effector T cells and infected target cells. Coinhibitory receptors are implicated not only in the suppression of immune responses to viruses by inhibition of effector T cells, but also in the persistence of infected cells in vivo. Here we review recent studies on coinhibitory receptors and their roles in retroviral infections such as HIV and HTLV-1. |
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| 書誌情報 |
Frontiers in Immunology 巻 9, 号 2755, p. 1-8, 発行年 2018-11-27 |
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| ISSN | ||||||
| 収録物識別子 | 16643224 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | https://doi.org/10.3389/fimmu.2018.02755 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 419802 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 出版者 | ||||||
| 出版者 | Frontiers Media | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | https://www.frontiersin.org/articles/10.3389/fimmu.2018.02755/full | |||||
