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Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts
http://hdl.handle.net/2298/00043544
http://hdl.handle.net/2298/000435445807a65a-ab67-40ed-8383-6f5b1be81f73
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
0960-894Xv27_4975-4978 (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-26 | |||||
| タイトル | ||||||
| タイトル | Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Notoamide, Enantiomer, Osteoclastogenesis, Aspergillus, Fungus | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kato, Hikaru
× Kato, Hikaru× Kai, Aika× Kawabata, Tetsuro× Sunderhaus, James D.× McAfoos, Timothy J.× Finefield, Jennifer M.× Sugimoto, Yukihiko× Williams, Robert M.× Tsukamoto, Sachiko |
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| 抄録 | ||||||
| 内容記述 | The marine-derived Aspergillus protuberus MF297-2 and the terrestrial A. amoenus NRRL 35600 produce enantiomeric prenylated indole alkaloids. Investigation of biological activities of the natural and synthetic derivatives revealed that (-)-enantiomers of notoamides A and B, 6-epi-notoamide T, and stephacidin A inhibited receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclastogenic differentiation of murine RAW264 cells more strongly than their respective (+)-enantiomers. Among them, (-)-6-epi-notoamide T was the most potent inhibitor with an IC50 value of 1.7 μM. | |||||
| 書誌情報 |
en : Bioorganic & Medicinal Chemistry Letters 巻 27, 号 22, p. 4975-4978, 発行年 2017-11-15 |
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| ISSN | ||||||
| 収録物識別子 | 0960-894X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.bmcl.2017.10.017 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2017 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 474.73 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.3 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
